Literature DB >> 6096866

Identification of a recent recombination event within the human beta-globin gene cluster.

D S Gerhard, K K Kidd, J R Kidd, J A Egeland, D E Housman.   

Abstract

In a detailed study of inheritance of DNA sequence polymorphism in a large reference pedigree, an individual was identified with an apparent genetic recombination event within the human beta-globin gene cluster. Analysis of the haplotypes of relevant individuals within this pedigree suggested that the meiotic crossing-over event is likely to have occurred within a 19.8-kilobase-pair region of the beta-globin gene cluster. Analysis of other DNA markers closely linked to the beta-globin gene cluster--segment 12 of chromosome 11 (D11S12) and loci for insulin, the cellular oncogene c-Ha-ras, and preproparathyroid hormone--confirmed that a crossover event must have occurred within the region of chromosome 11 between D11S12 and the beta-globin gene cluster. It is suggested that the event observed has occurred within a DNA region compatible with recombinational "hot spots" suggested by population studies.

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Year:  1984        PMID： 6096866      PMCID： PMC392255          DOI： 10.1073/pnas.81.24.7875

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  A computer program for linkage analysis of general human pedigrees.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1976-09       Impact factor: 11.025

3.  The linkage relationships of the beta and delta hemoglobin genes.

Authors:  G Stamatoyannopoulos; L R Weitkamp; P Kotsakis; A Akrivakis
Journal:  Hemoglobin       Date:  1977       Impact factor: 0.849

4.  Precise localization of human beta-globin gene complex on chromosome 11.

Authors:  J Gusella; A Varsanyi-Breiner; F T Kao; C Jones; T T Puck; C Keys; S Orkin; D Housman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Restriction endonuclease mapping of the human gamma globin gene loci.

Authors:  D Tuan; P A Biro; J K deRiel; H Lazarus; B G Forget
Journal:  Nucleic Acids Res       Date:  1979-06-11       Impact factor: 16.971

6.  Amish demography.

Authors:  H E Cross; V A McKusick
Journal:  Soc Biol       Date:  1970-06

7.  Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

Authors:  G I Bell; J H Karam; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

8.  Identification of potential ovomucoid mRNA precursors in chick oviduct nuclei.

Authors:  J L Nordstrom; D R Roop; M J Tsai; B W O'Malley
Journal:  Nature       Date:  1979-03-22       Impact factor: 49.962

9.  Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia.

Authors:  Y W Kan; K Y Lee; M Furbetta; A Angius; A Cao
Journal:  N Engl J Med       Date:  1980-01-24       Impact factor: 91.245

10.  DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man.

Authors:  A J Jeffreys
Journal:  Cell       Date:  1979-09       Impact factor: 41.582
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  15 in total

1.  Nonuniform recombination within the human beta-globin gene cluster: A reply to B. S. Weir and W. G. Hill.

Authors:  A Chakravarti; K H Buetow; S E Antonarakis; P G Waber; C D Boehm; H H Kazazian
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

2.  The same beta-globin gene mutation is present on nine different beta-thalassemia chromosomes in a Sardinian population.

Authors:  M Pirastu; R Galanello; M A Doherty; T Tuveri; A Cao; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

3.  Recombination of haplotypes leads to biased estimates of admixture proportions in human populations.

Authors:  R Chakraborty; P E Smouse
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

4.  Meiotic recombination between two polymorphic restriction sites within the beta globin gene cluster.

Authors:  J M Old; C Heath; A Fitches; S L Thein; A J Jeffreys; M Petrou; B Modell; D J Weatherall
Journal:  J Med Genet       Date:  1986-02       Impact factor: 6.318

Review 5.  The evolution of the alpha- and beta-globin gene clusters in human populations.

Authors:  A V Hill; J S Wainscoat
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

6.  High recombination between two physically close human basement membrane collagen genes at the distal end of chromosome 13q.

Authors:  A M Bowcock; J M Hebert; E Wijsman; I Gadi; L L Cavalli-Sforza; C D Boyd
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  Linkage analysis of a DNA marker localized to 20p12 and multiple endocrine neoplasia type 2A.

Authors:  P J Goodfellow; B N White; J J Holden; A M Duncan; E V Sears; H S Wang; L Berlin; K K Kidd; N E Simpson
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

8.  Polymorphisms of the immunoglobulin heavy-chain delta gene and association with other constant-region genes.

Authors:  J C Benger; D W Cox
Journal:  Am J Hum Genet       Date:  1989-10       Impact factor: 11.025

9.  Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

Authors:  L B Jorde; W S Watkins; M Carlson; J Groden; H Albertsen; A Thliveris; M Leppert
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

Review 10.  Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants.

Authors:  J Flint; R M Harding; J B Clegg; A J Boyce
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132
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