Literature DB >> 6096164

The H+/O ratio of proton translocation linked to the oxidation of succinate by mitochondria.

K Krab, J Soos, M Wikström.   

Abstract

In a recent communication Lehninger and co-workers (Costa, L.E., Reynaferje, B., and Lehninger, A.L. (1984) J. Biol. Chem. 259, 4802-4811) reported values approaching 8 for the H+/O ratio of vectorial proton ejection from rat liver mitochondria respiring with succinate. Here we present a rigorous analysis of these measurements which reveals that they may significantly overestimate the true H+/O stoicheiometry.

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Year:  1984        PMID： 6096164     DOI： 10.1016/0014-5793(84)80598-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

Review 1.  Is there sufficient experimental evidence to consider the mitochondrial cytochrome bc1 complex a proton pump? Probably no.

Authors:  M J Nałecz
Journal:  J Bioenerg Biomembr       Date:  1986-02       Impact factor: 2.945

2.  Inhibition of the phosphate-stimulated cytochrome c oxidase activity by thiophosphate.

Authors:  S Manon; N Camougrand; M Guerin
Journal:  J Bioenerg Biomembr       Date:  1989-06       Impact factor: 2.945

Review 3.  Problems in the experimental determination of substrate-specific H+/O ratios during respiration.

Authors:  R W Hendler; R I Shrager
Journal:  J Bioenerg Biomembr       Date:  1987-10       Impact factor: 2.945

Review 4.  Regulation of respiration and ATP synthesis in higher organisms: hypothesis.

Authors:  B Kadenbach
Journal:  J Bioenerg Biomembr       Date:  1986-02       Impact factor: 2.945

5.  Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.

Authors:  P J Honkakoski; I E Hassinen
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857
  5 in total

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