Literature DB >> 6095452

Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA.

T Matsuo, M Heller, L Petti, E O'Shiro, E Kieff.   

Abstract

The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.

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Year:  1984        PMID： 6095452     DOI： 10.1126/science.6095452

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  68 in total

1.  Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.

Authors:  M S Kang; S C Hung; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-04       Impact factor: 11.205

2.  Sp1 binds to the precise locus of end processing within the terminal repeats of Epstein-Barr virus DNA.

Authors:  R Sun; T A Spain; S F Lin; G Miller
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

3.  Marked variation in the size of genomic plasmids among members of a family of related Epstein-Barr viruses.

Authors:  J L Kolman; C J Kolman; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

4.  Epstein-Barr virus (EBV)-negative B-lymphoma cell lines for clonal isolation and replication of EBV recombinants.

Authors:  A Marchini; R Longnecker; E Kieff
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

5.  Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.

Authors:  G Gualandi; E Santolini; E Calef
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

6.  B-cell lymphoproliferation and lymphomagenesis are associated with clonotypic intracellular terminal regions of the Epstein-Barr virus.

Authors:  N A Brown; C R Liu; Y F Wang; C R Garcia
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

7.  In vitro transcription of baculovirus immediate early genes: accurate mRNA initiation by nuclear extracts from both insect and human cells.

Authors:  R R Hoopes; G F Rohrmann
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

8.  Activity of soluble factors produced by Epstein-Barr virus-transformed human B lymphocytes on different cell lines.

Authors:  C Garzelli; A Bazzichi
Journal:  Experientia       Date:  1991-07-15

9.  Structure and role of the terminal repeats of Epstein-Barr virus in processing and packaging of virion DNA.

Authors:  J Zimmermann; W Hammerschmidt
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

10.  When Epstein-Barr virus persistently infects B-cell lines, it frequently integrates.

Authors:  E A Hurley; S Agger; J A McNeil; J B Lawrence; A Calendar; G Lenoir; D A Thorley-Lawson
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103
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