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Literature DB >> 1323719

Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.

Abstract

We show here that in a lymphoblastoid cell line Epstein-Barr virus DNA recombines with the human genome. The genetic exchange involves the oriP region of the virus. A junction between viral and human DNA from this line has been cloned and sequenced. The results indicate that the integration of Epstein-Barr virus DNA involves a region of the human genome which contains internal short repetition. An 800-bp probe has been isolated from the human part of the junction. This probe has been used to show that the human region exists as a duplication in normal cells.

Entities: CellLine Species

Mesh：

Year: 1992 PMID： 1323719 PMCID： PMC289137

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

22 in total

1. The prototypical Epstein-Barr virus-transformed lymphoblastoid cell line IB4 is an unusual variant containing integrated but no episomal viral DNA.

Authors: E A Hurley; L D Klaman; S Agger; J B Lawrence; D A Thorley-Lawson
Journal: J Virol Date: 1991-07 Impact factor: 5.103

Review 2. An intricate route to immortality.

Authors: B Sugden
Journal: Cell Date: 1989-04-07 Impact factor: 41.582

3. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

Authors: D Reisman; J Yates; B Sugden
Journal: Mol Cell Biol Date: 1985-08 Impact factor: 4.272

4. Variable number of tandem repeat (VNTR) markers for human gene mapping.

Authors: Y Nakamura; M Leppert; P O'Connell; R Wolff; T Holm; M Culver; C Martin; E Fujimoto; M Hoff; E Kumlin
Journal: Science Date: 1987-03-27 Impact factor: 47.728

Review 5. The polymerase chain reaction.

Authors: T J White; N Arnheim; H A Erlich
Journal: Trends Genet Date: 1989-06 Impact factor: 11.639

6. Specific sites for EBV association in the Namalwa Burkitt lymphoma cell line and in a lymphoblastoid line transformed in vitro with EBV.

Authors: D Caporossi; P Vernole; B Porfirio; B Tedeschi; D Frezza; B Nicoletti; E Calef
Journal: Cytogenet Cell Genet Date: 1988

Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.

1. The prototypical Epstein-Barr virus-transformed lymphoblastoid cell line IB4 is an unusual variant containing integrated but no episomal viral DNA.

Review 2. An intricate route to immortality.

3. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

4. Variable number of tandem repeat (VNTR) markers for human gene mapping.

Review 5. The polymerase chain reaction.

6. Specific sites for EBV association in the Namalwa Burkitt lymphoma cell line and in a lymphoblastoid line transformed in vitro with EBV.

7. Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA.

8. Evidence for integrated EBV genomes in Raji cellular DNA.

9. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

10. Immortalization of monkey epithelial cells by specific fragments of Epstein-Barr virus DNA.

Review 1. The search for a gene involved in the determination of limited duplicative capacity in human cells.