Literature DB >> 6094294

Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue.

K Yaginuma, H Kobayashi, E Yoshida, M Kobayashi, K Koike.   

Abstract

The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.

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Year:  1984        PMID： 6094294

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  7 in total

1.  Subgenomic studies on hepatitis B virus DNA integrated into the genome of hepatocellular carcinoma.

Authors:  K Togawa; T Arima; H Nagashima
Journal:  Gastroenterol Jpn       Date:  1987-10

2.  Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children.

Authors:  K Yaginuma; H Kobayashi; M Kobayashi; T Morishima; K Matsuyama; K Koike
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

3.  Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

Authors:  K Yaginuma; M Kobayashi; E Yoshida; K Koike
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

4.  Structure and expression of integrated hepatitis B virus genes in an HBs antigen producing human cell line (huGK-14).

Authors:  N Nakamichi; A Noda; T Yonezu; K Koike; T Matsumura
Journal:  Cytotechnology       Date:  1997-11       Impact factor: 2.058

Review 5.  Hepatitis B virus infection and primary hepatocellular carcinoma.

Authors:  M Feitelson
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

6.  Age-related, different clinicopathologic features of hepatocellular carcinoma patients.

Authors:  T Namieno; A Kawata; N Sato; Y Kondo; J Uchino
Journal:  Ann Surg       Date:  1995-03       Impact factor: 12.969

7.  Hepatitis B virus DNA detection by in situ hybridization in human hepatocellular carcinoma.

Authors:  D H Lee; J D Lee
Journal:  Korean J Intern Med       Date:  1988-01       Impact factor: 2.884
  7 in total

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