Literature DB >> 6092461

Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency.

S Kohl, T A Springer, F C Schmalstieg, L S Loo, D C Anderson.   

Abstract

Four children with an immunodeficiency involving the absence of leukocyte membrane glycoproteins reacting with anti-LFA-1 and OKM-1 monoclonal antibodies were unable to mediate adherence-dependent leukocyte functions. Even with normal Fc receptor function, their PMN-ADCC and MC-NKC were markedly deficient. Single cell analysis demonstrated deficient antibody-mediated PMN-target cell adherence. Monoclonal antibodies against LFA-1 and OKM-1 reproduced this immunodeficiency in leukocytes from normal adults. LFA-1/OKM-1 mediates a PMN-target cell adhesive step.

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Year:  1984        PMID： 6092461

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  38 in total

Review 1.  The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion.

Authors:  M A Kerr; S C Stocks
Journal:  Histochem J       Date:  1992-11

2.  The mature activating natural killer cell immunologic synapse is formed in distinct stages.

Authors:  Jordan S Orange; K Eliza Harris; Milena M Andzelm; Markus M Valter; Raif S Geha; Jack L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-11       Impact factor: 11.205

3.  Functional surface structures on human natural killer cells.

Authors:  R E Schmidt; T Hercend; S F Schlossman; J Ritz
Journal:  Klin Wochenschr       Date:  1985-12-02

Review 4.  The role of leukocyte adhesion molecules in cellular interactions: implications for the pathogenesis of inflammatory synovitis.

Authors:  B F Haynes; L P Hale; S M Denning; P T Le; K H Singer
Journal:  Springer Semin Immunopathol       Date:  1989

Review 5.  Formation and function of the lytic NK-cell immunological synapse.

Authors:  Jordan S Orange
Journal:  Nat Rev Immunol       Date:  2008-09       Impact factor: 53.106

6.  Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling.

Authors:  Ashley Mentlik James; Hsiang-Ting Hsu; Prachi Dongre; Gulbu Uzel; Emily M Mace; Pinaki P Banerjee; Jordan S Orange
Journal:  Blood       Date:  2013-02-04       Impact factor: 22.113

7.  The effect of different anesthetics on tumor cytotoxicity by natural killer cells.

Authors:  Kazumasa Tazawa; Sophia Koutsogiannaki; Matthew Chamberlain; Koichi Yuki
Journal:  Toxicol Lett       Date:  2016-12-08       Impact factor: 4.372

Review 8.  Infections in patients with inherited defects in phagocytic function.

Authors:  Timothy Andrews; Kathleen E Sullivan
Journal:  Clin Microbiol Rev       Date:  2003-10       Impact factor: 26.132

9.  LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells.

Authors:  S D Marlin; C C Morton; D C Anderson; T A Springer
Journal:  J Exp Med       Date:  1986-09-01       Impact factor: 14.307

10.  Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.

Authors:  Ashley N Mentlik; Keri B Sanborn; Erika L Holzbaur; Jordan S Orange
Journal:  Mol Biol Cell       Date:  2010-05-05       Impact factor: 4.138
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