Literature DB >> 19172692

Formation and function of the lytic NK-cell immunological synapse.

Jordan S Orange1.   

Abstract

The natural killer (NK)-cell immunological synapse is the dynamic interface formed between an NK cell and its target cell. Formation of the NK-cell immunological synapse involves several distinct stages, from the initiation of contact with a target cell to the directed delivery of lytic-granule contents for target-cell lysis. Progression through the individual stages is regulated, and this tight regulation underlies the precision with which NK cells select and kill susceptible target cells (including virally infected cells and cancerous cells) that they encounter during their routine surveillance of the body.

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Year:  2008        PMID： 19172692      PMCID： PMC2772177          DOI： 10.1038/nri2381

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  136 in total

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