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Literature DB >> 6091840

Metabolic effects of bicarbonate in the treatment of diabetic ketoacidosis.

Abstract

The effect of intravenous bicarbonate on the changes in intermediary metabolites during the initial treatment of diabetic ketoacidosis was examined in 16 patients. The results were compared with the changes seen in 16 patients receiving intravenous saline. Infusion of 150 mmol (mEq) bicarbonate significantly delayed the fall in blood lactate, lactate:pyruvate ratio, and total ketone bodies observed in the saline treated group. No difference in the rate of fall of blood glucose concentration was found. There is no metabolic indication for the use of intravenous bicarbonate in the treatment of diabetic ketoacidosis.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6091840 PMCID： PMC1443021 DOI： 10.1136/bmj.289.6451.1035

Source DB: PubMed Journal: Br Med J (Clin Res Ed) ISSN： 0267-0623

24 in total

1. Effect of ketone infusions on amino acid and nitrogen metabolism in man.

Authors: R S Sherwin; R G Hendler; P Felig
Journal: J Clin Invest Date: 1975-06 Impact factor: 14.808

2. The oxygen transport system of red blood cells during diabetic ketoacidosis and recovery.

Authors: J Ditzel; E Standl
Journal: Diabetologia Date: 1975-08 Impact factor: 10.122

3. Lactic acidosis in diabetic patients.

Authors: M Fulop; H D Hoberman; J H Rascoff; N A Bonheim; N P Dreyer; H Tannenbaum
Journal: Arch Intern Med Date: 1976-09

4. A kinetic spectrophotometric assay for rapid determination of acetoacetate in blood.

Authors: C P Price; B Llyod; G M Alberti
Journal: Clin Chem Date: 1977-10 Impact factor: 8.327

5. Intracellular organic phosphates as regulators of oxygen release by haemoglobin.

Authors: R Benesch; R E Benesch
Journal: Nature Date: 1969-02-15 Impact factor: 49.962

6. Acute diabetic ketoacidosis in children: role of the stress hormones.

Authors: M H MacGillivray; E Bruck; M L Voorhess
Journal: Pediatr Res Date: 1981-02 Impact factor: 3.756

7. Effects of changes of pH and of carbon dioxide tension on left ventricular performance.

Authors: M L Ng; M N Levy; H A Zieske
Journal: Am J Physiol Date: 1967-07

8. Lactic acidosis in diabetes.

Authors: P J Watkins; J S Smith; M G Fitzgerald; J M Malins
Journal: Br Med J Date: 1969-03-22

Review 9. Lactic acidosis: current concepts.

Authors: R Park; A I Arieff
Journal: Clin Endocrinol Metab Date: 1983-07

10. Impaired insulin binding to isolated adipocytes in experimental diabetic ketoacidosis.

Authors: J Whittaker; C Cuthbert; V Hammond; K G Alberti
Journal: Diabetologia Date: 1981-12 Impact factor: 10.122

14 in total

Review 1. Emergency management of diabetic ketoacidosis in adults.

Authors: R D Hardern; N D Quinn
Journal: Emerg Med J Date: 2003-05 Impact factor: 2.740

2. Diabetic ketoacidosis: current views on pathogenesis and treatment.

Authors: U Keller
Journal: Diabetologia Date: 1986-02 Impact factor: 10.122

Review 3. Diabetic ketoacidosis.

Authors: D G Patel; S C Kalhan
Journal: Indian J Pediatr Date: 1986 Sep-Oct Impact factor: 1.967

4. Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis.

Authors: D J Cooper; L I Worthley
Journal: Intensive Care Med Date: 1987 Impact factor: 17.440

5. Characterisation of metabolic acidosis in Kenyan children admitted to hospital for acute non-surgical conditions.

Authors: P Sasi; M English; J Berkley; B Lowe; M Shebe; R Mwakesi; G Kokwaro
Journal: Trans R Soc Trop Med Hyg Date: 2005-10-27 Impact factor: 2.184

Review 6. Management of diabetic ketoacidosis.

Authors: T H Sanson; S N Levine
Journal: Drugs Date: 1989-08 Impact factor: 9.546