| Literature DB >> 6091772 |
J K Heath, S J Atkinson, M C Meikle, J J Reynolds.
Abstract
Bone cells isolated from mouse calvariae by a sequential digestion procedure have many osteoblast characteristics: they respond to PTH and prostaglandin E2 by activation of adenylate cyclase but not to calcitonin, they stain for alkaline phosphatase and they make only type I collagen. In confluent monolayer culture, they do not secrete collagenase in appreciable quantities, unless stimulated with resorptive substances such as PTH, prostaglandin E2, 1,25(OH)2 vitamin D-3 and monocyte-conditioned medium. This suggests they play a direct role in bone resorption.Entities:
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Year: 1984 PMID： 6091772 DOI： 10.1016/0304-4165(84)90046-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002