Literature DB >> 3030273

Direct extraction and assay of bone tissue collagenase and its relation to parathyroid-hormone-induced bone resorption.

Y Eeckhout, J M Delaissé, G Vaes.   

Abstract

A method has been developed for the quantitative extraction of collagenase from as little as one 19-day-fetal-mouse calvarium. About 20-40 munits of collagenase are extracted per mg of tissue, all in a latent form that, after proper activation, shows the typical properties of mammalian collagenase. Culturing the calvaria for 2 days with parathyroid hormone (PTH) increases their procollagenase content up to 3-fold and induces bone resorption. Both PTH effects are prevented by cycloheximide, but not by indomethacin. Calcitonin inhibits resorption without affecting the PTH-induced procollagenase synthesis. The role of this synthesis is discussed in relation to the mechanisms of bone resorption.

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Year:  1986        PMID： 3030273      PMCID： PMC1147359          DOI： 10.1042/bj2390793

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen.

Authors:  T E Cawston; A J Barrett
Journal:  Anal Biochem       Date:  1979-11-01       Impact factor: 3.365

2.  Evidence that latent collagenases are enzyme-inhibitor complexes.

Authors:  A Sellers; E Cartwright; G Murphy; J J Reynolds
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

3.  Purification of procollagenase and collagenase by affinity chromatography on Sepharose-collagen.

Authors:  C Gillet; Y Eeckhout; G Vaes
Journal:  FEBS Lett       Date:  1977-02-15       Impact factor: 4.124

4.  Extraction of collagenase from the involuting rat uterus.

Authors:  J G Weeks; J Halme; J F Woessner
Journal:  Biochim Biophys Acta       Date:  1976-08-12

5.  A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture.

Authors:  J M Delaissé; Y Eeckhout; C Sear; A Galloway; K McCullagh; G Vaes
Journal:  Biochem Biophys Res Commun       Date:  1985-12-17       Impact factor: 3.575

6.  Role of osteoblasts in hormonal control of bone resorption--a hypothesis.

Authors:  G A Rodan; T J Martin
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

7.  The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor.

Authors:  T E Cawston; G Murphy; E Mercer; W A Galloway; B L Hazleman; J J Reynolds
Journal:  Biochem J       Date:  1983-05-01       Impact factor: 3.857

8.  Collagenase, procollagenase and bone resorption. Effects of heparin, parathyroid hormone and calcitonin.

Authors:  G Lenaers-Claeys; G Vaes
Journal:  Biochim Biophys Acta       Date:  1979-05-16

9.  On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells.

Authors:  G Vaes
Journal:  J Cell Biol       Date:  1968-12       Impact factor: 10.539

10.  Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat.

Authors:  H Warshawsky; D Goltzman; M F Rouleau; J J Bergeron
Journal:  J Cell Biol       Date:  1980-06       Impact factor: 10.539
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  12 in total

1.  Possible role and mechanism of action of dissolved calcium in the degradation of bone collagen by lysosomal cathepsins and collagenase.

Authors:  Y Eeckhout
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

2.  Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual block by ovarian steroids.

Authors:  C F Singer; E Marbaix; I Kokorine; P Lemoine; J Donnez; Y Eeckhout; P J Courtoy
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

3.  Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption.

Authors:  V Everts; W Beertsen; R Schröder
Journal:  Calcif Tissue Int       Date:  1988-09       Impact factor: 4.333

4.  Action of metalloproteinases on porcine dentin mineralization.

Authors:  M Fukae; T Tanabe; M Yamada
Journal:  Calcif Tissue Int       Date:  1994-12       Impact factor: 4.333

5.  In vivo perimenstrual activation of progelatinase B (proMMP-9) in the human endometrium and its dependence on stromelysin 1 (MMP-3) ex vivo.

Authors:  V Rigot; E Marbaix; P Lemoine; P J Courtoy; Y Eeckhout
Journal:  Biochem J       Date:  2001-08-15       Impact factor: 3.857

6.  Age-related thermal stability and susceptibility to proteolysis of rat bone collagen.

Authors:  C C Danielsen
Journal:  Biochem J       Date:  1990-12-15       Impact factor: 3.857

7.  Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.

Authors:  P A Hill; A J Docherty; K M Bottomley; J P O'Connell; J R Morphy; J J Reynolds; M C Meikle
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

8.  Differentiation of human osteoblastic cells in culture: modulation of proteases by extracellular matrix and tumor necrosis factor-alpha.

Authors:  F S Panagakos; S Kumar
Journal:  Inflammation       Date:  1995-08       Impact factor: 4.092

9.  An active neutral metalloproteinase bound to the insoluble collagen in the mineralized phase matrix of adult rat calvaria.

Authors:  M Fukae; T Tanabe; M Yamada
Journal:  Calcif Tissue Int       Date:  1992-08       Impact factor: 4.333

10.  Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants.

Authors:  E Marbaix; J Donnez; P J Courtoy; Y Eeckhout
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205
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