Literature DB >> 6091650

Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin.

J Levy, I Teuerstein, M Marbach, S Radian, Y Sharoni.   

Abstract

Tyrosine protein kinase activity was measured in membranes from DMBA-induced mammary tumors, with Angiotensin II as substrate. The apparent Km for the peptide was 3.3 mM. This enzymatic activity is inhibited by Ca+2; Mn+2 can replace Mg+2 with an increase in the Km for ATP from 47 /microM to 172 microM. The enzymatic activity was not affected by cyclic AMP but was inhibited in dose dependent manner by quercetin, a bioflavonoid which is known to inhibit proliferation of malignant cells in vitro.

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Year:  1984        PMID： 6091650     DOI： 10.1016/s0006-291x(84)80264-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: possible involvement of HSP 72.

Authors:  Harlokesh Narayan Yadav; Manjeet Singh; Pyare Lal Sharma
Journal:  Mol Cell Biochem       Date:  2012-07-19       Impact factor: 3.396

Review 2.  Wine as a biological fluid: history, production, and role in disease prevention.

Authors:  G J Soleas; E P Diamandis; D M Goldberg
Journal:  J Clin Lab Anal       Date:  1997       Impact factor: 2.352

3.  Quantification of the flavonoid-degrading bacterium Eubacterium ramulus in human fecal samples with a species-specific oligonucleotide hybridization probe.

Authors:  R Simmering; B Kleessen; M Blaut
Journal:  Appl Environ Microbiol       Date:  1999-08       Impact factor: 4.792

4.  Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.

Authors:  Y T Huang; J J Hwang; P P Lee; F C Ke; J H Huang; C J Huang; C Kandaswami; E Middleton; M T Lee
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

5.  PLGA nanoparticles loaded with etoposide and quercetin dihydrate individually: in vitro cell line study to ensure advantage of combination therapy.

Authors:  Smita Pimple; Arehalli S Manjappa; Mukesh Ukawala; R S R Murthy
Journal:  Cancer Nanotechnol       Date:  2012-05-09

6.  Differential distribution of protein kinases along the crypt-to-lumen regions of rat colonic epithelium.

Authors:  B Schwartz; G M Fraser; J Levy; Y Sharoni; R Guberman; J Krawiec; S A Lamprecht
Journal:  Gut       Date:  1988-09       Impact factor: 23.059

7.  Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana.

Authors:  Wendy Ann Peer; Anindita Bandyopadhyay; Joshua J Blakeslee; Srinivas N Makam; Rujin J Chen; Patrick H Masson; Angus S Murphy
Journal:  Plant Cell       Date:  2004-06-18       Impact factor: 11.277

8.  Mechanism of quercetin-induced suppression and delay of heat shock gene expression and thermotolerance development in HT-29 cells.

Authors:  Y J Lee; G Erdos; Z Z Hou; S H Kim; J H Kim; J M Cho; P M Corry
Journal:  Mol Cell Biochem       Date:  1994-08-31       Impact factor: 3.396

9.  Biochemical characteristics of cytosolic and particulate forms of protein tyrosine kinases from N-methyl-N-nitrosourea (MNU)-induced rat mammary carcinoma.

Authors:  A K Srivastava; J C Chiasson; J L Chiasson; A Lacroix; L Windisch
Journal:  Mol Cell Biochem       Date:  1991-07-24       Impact factor: 3.396

10.  Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

Authors:  F Carrier; R A Owens; D W Nebert; A Puga
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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