Literature DB >> 6091043

Analysis of immunoglobulin heavy chain V-region genes belonging to the V NP-gene family.

T Blankenstein, G Zoebelein, U Krawinkel.   

Abstract

A method was devised to clone immunoglobulin VH-region genes located on selected restriction fragments from genomic DNA directly into M13 vectors for subsequent nucleotide sequence analysis. Ten recombinant M13 clones representing four so far unknown VH-region genes of the VNP-gene family have been analysed. Sequence comparison shows that these genes are closely related to other VH-genes of the VNP gene family. One of the VH-genes exhibits a so far unobserved unusual length of 100 2/3 codons and appears to be functional. Analysis of the variation of the isolated VH-genes suggests that framework and complementarity determining regions are exposed to separate types of selective pressures.

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Year:  1984        PMID： 6091043      PMCID： PMC320124          DOI： 10.1093/nar/12.17.6887

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  31 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

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Journal:  Nature       Date:  1979-07-26       Impact factor: 49.962

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Journal:  Cell       Date:  1978-12       Impact factor: 41.582

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Authors:  M Reth; G J Hämmerling; K Rajewsky
Journal:  Eur J Immunol       Date:  1978-06       Impact factor: 5.532

5.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

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Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

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Authors:  J Schilling; B Clevinger; J M Davie; L Hood
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962

8.  The joining of V and J gene segments creates antibody diversity.

Authors:  M Weigert; R Perry; D Kelley; T Hunkapiller; J Schilling; L Hood
Journal:  Nature       Date:  1980-01-31       Impact factor: 49.962

9.  The structure and evolution of the two nonallelic rat preproinsulin genes.

Authors:  P Lomedico; N Rosenthal; A Efstratidadis; W Gilbert; R Kolodner; R Tizard
Journal:  Cell       Date:  1979-10       Impact factor: 41.582

10.  Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran.

Authors:  B Clevinger; J Schilling; L Hood; J M Davie
Journal:  J Exp Med       Date:  1980-05-01       Impact factor: 14.307
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  8 in total

1.  Evolution of pseudogenes in the immunoglobulin VH-gene family of the mouse.

Authors:  T Blankenstein; F Bonhomme; U Krawinkel
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

2.  Dynamic gene interactions in the evolution of rabbit VH genes: a four codon duplication and block homologies provide evidence for intergenic exchange.

Authors:  W T McCormack; S M Laster; W F Marzluff; K H Roux
Journal:  Nucleic Acids Res       Date:  1985-10-11       Impact factor: 16.971

3.  Immunoglobulin VH gene sequence analysis of spontaneous murine immunoglobulin-secreting B-cell tumours with clinical features of human disease.

Authors:  D Zhu; C van Arkel; C A King; S V Meirvenne; C de Greef; K Thielemans; J Radl; F K Stevenson
Journal:  Immunology       Date:  1998-02       Impact factor: 7.397

4.  Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

Authors:  E Winter; A Radbruch; U Krawinkel
Journal:  EMBO J       Date:  1985-11       Impact factor: 11.598

5.  Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

Authors:  A Cumano; K Rajewsky
Journal:  EMBO J       Date:  1986-10       Impact factor: 11.598

6.  Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.

Authors:  C Schiff; M Milili; M Fougereau
Journal:  EMBO J       Date:  1985-05       Impact factor: 11.598

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Authors:  H Gu; D Tarlinton; W Müller; K Rajewsky; I Förster
Journal:  J Exp Med       Date:  1991-06-01       Impact factor: 14.307

8.  B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells.

Authors:  P Lane; C Burdet; S Hubele; D Scheidegger; U Müller; F McConnell; M Kosco-Vilbois
Journal:  J Exp Med       Date:  1994-03-01       Impact factor: 14.307
  8 in total

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