Literature DB >> 6090468

Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin.

M Ascoli.   

Abstract

The experiments presented herein were designed to determine the fate of the human choriogonadotropin (hCG) receptor during endocytosis of the receptor-bound hCG. Using several biochemical approaches, it is shown that the receptor is internalized together with the hormone into endocytic vesicles and transferred to lysosomes without ligand dissociation. Once delivered to the lysosomes, the hCG-receptor complex dissociates, and the free hormone is degraded. This pathway appears to prevent receptor recycling and probably promotes receptor degradation.

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Year:  1984        PMID： 6090468      PMCID： PMC2113298          DOI： 10.1083/jcb.99.4.1242

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  33 in total

1.  Inhibition of the degradation of receptor-bound human choriogonadotropin by leupeptin.

Authors:  M Ascoli
Journal:  Biochim Biophys Acta       Date:  1979-09-03

2.  Degradation of receptor-bound human choriogonadotropin by murine Leydig tumor cells.

Authors:  M Ascoli; D Puett
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157

Review 3.  Enzymic diagnosis of the genetic mucopolysaccharide storage disorders.

Authors:  C W Hall; I Liebaers; P Di Natale; E F Neufeld
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

4.  Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

Authors:  S Ohkuma; B Poole
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

5.  Inhibition of the degradation of receptor-bound human choriogonadotropin by lysosomotropic agents, protease inhibitors, and metabolic inhibitors.

Authors:  M Ascoli; D Puett
Journal:  J Biol Chem       Date:  1978-11-10       Impact factor: 5.157

6.  Two species of lysosomal organelles in cultured human fibroblasts.

Authors:  L H Rome; A J Garvin; M M Allietta; E F Neufeld
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

7.  The use of intensifying screens or organic scintillators for visualizing radioactive molecules resolved by gel electrophoresis.

Authors:  R A Laskey
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

8.  Coated pits, coated vesicles, and receptor-mediated endocytosis.

Authors:  J L Goldstein; R G Anderson; M S Brown
Journal:  Nature       Date:  1979-06-21       Impact factor: 49.962

9.  Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

Authors:  H T Haigler; J A McKanna; S Cohen
Journal:  J Cell Biol       Date:  1979-05       Impact factor: 10.539

10.  125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

Authors:  G Carpenter; S Cohen
Journal:  J Cell Biol       Date:  1976-10       Impact factor: 10.539
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  10 in total

1.  Decreased degradation of internalized follicle-stimulating hormone caused by mutation of aspartic acid 6.30(550) in a protein kinase-CK2 consensus sequence in the third intracellular loop of human follicle-stimulating hormone receptor.

Authors:  Kerri S Kluetzman; Richard M Thomas; Cheryl A Nechamen; James A Dias
Journal:  Biol Reprod       Date:  2011-01-26       Impact factor: 4.285

2.  Distribution of insulin binding sites on Leydig cells of rat testes using insulin-coated gold particles.

Authors:  M Kimura; A Lukinius; J L Ericsson; L Grimelius
Journal:  Histochemistry       Date:  1992

Review 3.  Endosome maturation.

Authors:  Jatta Huotari; Ari Helenius
Journal:  EMBO J       Date:  2011-08-31       Impact factor: 11.598

4.  A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation.

Authors:  Colette Galet; Mario Ascoli
Journal:  Mol Endocrinol       Date:  2006-06-27

5.  Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes.

Authors:  P Ukkonen; V Lewis; M Marsh; A Helenius; I Mellman
Journal:  J Exp Med       Date:  1986-04-01       Impact factor: 14.307

6.  Chloroquine interaction with inflammatory human polymorphonuclear leucocytes.

Authors:  M Raghoebar; J A Huisman; W B van den Berg; P L van Riel; C A van Ginneken
Journal:  Agents Actions       Date:  1988-07

7.  Surface retention of an inactivating lutropin receptor mutant in exoloop 3.

Authors:  N Bhowmick; P Narayan; D Puett
Journal:  Mol Cell Biochem       Date:  1998-10       Impact factor: 3.396

8.  Differences in internalization and intracellular processing of interleukin-1 associated with the two forms of interleukin-1 receptor found in B-cells and T-cells.

Authors:  R Horuk
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857

9.  Pathways of internalization of the hCG/LH receptor: immunoelectron microscopic studies in Leydig cells and transfected L-cells.

Authors:  N Ghinea; M T Vu Hai; M T Groyer-Picard; A Houllier; D Schoëvaërt; E Milgrom
Journal:  J Cell Biol       Date:  1992-09       Impact factor: 10.539

10.  Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

Authors:  W A Dunn; T P Connolly; A L Hubbard
Journal:  J Cell Biol       Date:  1986-01       Impact factor: 10.539
  10 in total

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