Literature DB >> 6090206

Endopeptidase-24.11 and aminopeptidase activity in brain synaptic membranes are jointly responsible for the hydrolysis of cholecystokinin octapeptide (CCK-8).

R Matsas, A J Turner, A J Kenny.   

Abstract

Endopeptidase-24.11 (EC 3.4.24.11) from pig kidney hydrolysed CCK-8 (sulphated) at two distinct sites: Asp-Tyr(SO3H)-Met-Gly Trp-Met-Asp PheNH2. Under initial conditions, the splitting of the Asp7-Phe8NH2 bond proceeded 4-times more rapidly than the Gly4-Trp5 bond. Pig brain striatal synaptic membranes attacked this substrate at the same sites and this activity was inhibited by phosphoramidon. However, other products were detected even in the presence of phosphoramidon. One of these products was identified as free tryptophan. Since their formation was inhibited by bestatin, one or more membrane aminopeptidases is also implicated in the degradation of CCK-8.

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Year:  1984        PMID： 6090206     DOI： 10.1016/0014-5793(84)80583-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P.

Authors:  R Matsas; M Rattray; A J Kenny; A J Turner
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

2.  CD13/APN is activated by angiogenic signals and is essential for capillary tube formation.

Authors:  S V Bhagwat; J Lahdenranta; R Giordano; W Arap; R Pasqualini; L H Shapiro
Journal:  Blood       Date:  2001-02-01       Impact factor: 22.113

3.  An immunoradiometric assay for endopeptidase-24.11 shows it to be a widely distributed enzyme in pig tissues.

Authors:  N S Gee; M A Bowes; P Buck; A J Kenny
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857

4.  The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.

Authors:  S L Stephenson; A J Kenny
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

5.  The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N.

Authors:  R Matsas; S L Stephenson; J Hryszko; A J Kenny; A J Turner
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857

6.  Effect of protease inhibitors on peptide-stimulated amylase secretion from dispersed pancreatic acini.

Authors:  Q J Wang; T E Adrian
Journal:  Int J Pancreatol       Date:  1995-06

7.  Endopeptidase-24.11 in pig lymph nodes. Purification and immunocytochemical localization in reticular cells.

Authors:  M A Bowes; A J Kenny
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

8.  A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain.

Authors:  C Rose; A Camus; J C Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

9.  Impaired angiogenesis in aminopeptidase N-null mice.

Authors:  Roberto Rangel; Yan Sun; Liliana Guzman-Rojas; Michael G Ozawa; Jessica Sun; Ricardo J Giordano; Carolyn S Van Pelt; Peggy T Tinkey; Richard R Behringer; Richard L Sidman; Wadih Arap; Renata Pasqualini
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-07       Impact factor: 11.205

10.  The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme).

Authors:  N M Hooper; A J Kenny; A J Turner
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857
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