Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effects of cAMP on single cell motility in Dictyostelium.

Literature DB >> 6088555

Effects of cAMP on single cell motility in Dictyostelium.

Abstract

The motility of individual, aggregation-competent amebae of Dictyostelium has been analyzed at different concentrations of cAMP under both nongradient and gradient conditions. The following is demonstrated: (a) concentrations of cAMP greater than 10(-8) M inhibit motility in a concentration-dependent fashion, decrease the frequency but not the degree of turning, and cause rounding in cell shape; (b) no concentration of cAMP stimulates motility, or positive chemokinesis; (c) concentrations of cAMP that stimulate a maximal chemotactic response do not affect motility and concentrations of cAMP that maximally inhibit motility do not stimulate chemotaxis under gradient conditions; and (d) the concentrations of cAMP that inhibit motility are identical under gradient and nongradient conditions.

Entities: Chemical

Mesh：

Substances：
Cyclic AMP

Year: 1984 PMID： 6088555 PMCID： PMC2113391 DOI： 10.1083/jcb.99.3.1151

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

21 in total

1. Morphogenesis in the slime mold Dictyostelium discoideum. 1. The accumulation and erasure of "morphogenetic information".

Authors: D R Soll; D R Waddell
Journal: Dev Biol Date: 1975-12 Impact factor: 3.582

2. Chemotaxis and binding of cyclic AMP in cellular slime molds.

Authors: J M Mato; T M Konijn
Journal: Biochim Biophys Acta Date: 1975-04-07

3. Cell differentiation without morphogenesis in Dictyostelium discoideum.

Authors: C D Town; J D Gross; R R Kay
Journal: Nature Date: 1976-08-19 Impact factor: 49.962

Review 4. Cyclic AMP receptors and the control of cell aggregation in Dictyostelium.

Authors: G Gerisch; D Malchow
Journal: Adv Cyclic Nucleotide Res Date: 1976

5. Requirement for cell differentiation in Dictyostelium discoideum.

Authors: R R Kay; D Garrod; R Tilly
Journal: Nature Date: 1978-01-05 Impact factor: 49.962

6. Signal propagation during aggregation in the slime mould Dictyostelium discoideum.

Authors: F Alcantara; M Monk
Journal: J Gen Microbiol Date: 1974-12

7. The cellular basis of movement of the migrating grex of the slime mould Dictyostelium discoideum: chemotactic and reaggregation behaviour of grex cells.

Authors: D R Garrod
Journal: J Embryol Exp Morphol Date: 1974-08

8. Alternative developmental pathways determined by environmental conditions in the cellular slime mold Dictyostelium discoideum.

Authors: P C Newell; A Telser; M Sussman
Journal: J Bacteriol Date: 1969-11 Impact factor: 3.490

9. Stationary phase and the cell cycle of Dictyostelium discoideum in liquid nutrient medium.

Authors: D R Soll; J Yarger; M Mirick
Journal: J Cell Sci Date: 1976-05 Impact factor: 5.285

10. Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum.

Authors: J T Bonner
Journal: Proc Natl Acad Sci U S A Date: 1970-01 Impact factor: 11.205

41 in total

1. The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.

Authors: D J Wessels; H Zhang; J Reynolds; K Daniels; P Heid; S Lu; A Kuspa; G Shaulsky; W F Loomis; D R Soll
Journal: Mol Biol Cell Date: 2000-08 Impact factor: 4.138

Effects of cAMP on single cell motility in Dictyostelium.

1. Morphogenesis in the slime mold Dictyostelium discoideum. 1. The accumulation and erasure of "morphogenetic information".

2. Chemotaxis and binding of cyclic AMP in cellular slime molds.

3. Cell differentiation without morphogenesis in Dictyostelium discoideum.

Review 4. Cyclic AMP receptors and the control of cell aggregation in Dictyostelium.

5. Requirement for cell differentiation in Dictyostelium discoideum.

6. Signal propagation during aggregation in the slime mould Dictyostelium discoideum.

7. The cellular basis of movement of the migrating grex of the slime mould Dictyostelium discoideum: chemotactic and reaggregation behaviour of grex cells.

8. Alternative developmental pathways determined by environmental conditions in the cellular slime mold Dictyostelium discoideum.

9. Stationary phase and the cell cycle of Dictyostelium discoideum in liquid nutrient medium.

10. Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum.

1. The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.

2. An unconventional myosin required for cell polarization and chemotaxis.

3. Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxis.

4. Behavioral studies into the mechanism of eukaryotic chemotaxis.

5. High fidelity information processing in folic acid chemotaxis of Dictyostelium amoebae.

6. The local cell curvature guides pseudopodia towards chemoattractants.

7. Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.

8. Dictyostelium discoideum myosin: isolation and characterization of cDNAs encoding the regulatory light chain.

9. Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia.

10. Myosin II is essential for the spatiotemporal organization of traction forces during cell motility.