Literature DB >> 6088300

The prostaglandin inhibitor effect of antiinflammatory drugs in the therapy of male infertility.

J Barkay, S Harpaz-Kerpel, S Ben-Ezra, S Gordon, H Zuckerman.   

Abstract

The effects of various doses of indomethacin and ketoprofen as compared with placebo were examined in 100 oligospermic patients who participated in this study. It was found that the treatment increased sperm count, sperm motility, and fertilizing capacity. The radioimmunoassay examination showed an increase in plasma follicle-stimulating hormone and luteinizing hormone but a decrease in testosterone. The results show that the influence of indomethacin was better in the dose of 75 mg daily. The mechanism of those changes is not clear. Treatment should be at least 60 days.

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Year:  1984        PMID: 6088300     DOI: 10.1016/s0015-0282(16)48081-7

Source DB:  PubMed          Journal:  Fertil Steril        ISSN: 0015-0282            Impact factor:   7.329


  8 in total

1.  The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia.

Authors:  S Aydin; O Inci; B Alagöl
Journal:  Int Urol Nephrol       Date:  1995       Impact factor: 2.370

Review 2.  [Drug therapy options for oligoasthenoteratozoospermia syndrome].

Authors:  M Trottmann; F M Köhn; M Dickmann; C G Stief; A J Becker
Journal:  Urologe A       Date:  2011-01       Impact factor: 0.639

Review 3.  The effects of drugs on sperm.

Authors:  J O Drife
Journal:  Drugs       Date:  1987-06       Impact factor: 9.546

Review 4.  FDA-approved drugs that are spermatotoxic in animals and the utility of animal testing for human risk prediction.

Authors:  Elizabeth R Rayburn; Liang Gao; Jiayi Ding; Hongxia Ding; Jun Shao; Haibo Li
Journal:  J Assist Reprod Genet       Date:  2017-10-24       Impact factor: 3.412

Review 5.  Advances in the evaluation and treatment of the infertile man.

Authors:  E D Kim; L I Lipshultz
Journal:  World J Urol       Date:  1997       Impact factor: 4.226

Review 6.  Guidelines for drug treatment of male infertility.

Authors:  G Haidl; W B Schill
Journal:  Drugs       Date:  1991-01       Impact factor: 9.546

7.  Tamoxifen is a potent antioxidant modulator for sperm quality in patients with idiopathic oligoasthenospermia.

Authors:  Li Guo; Jun Jing; Yu-Ming Feng; Bing Yao
Journal:  Int Urol Nephrol       Date:  2015-07-28       Impact factor: 2.370

8.  Nonsurgical treatment of male infertility: specific and empiric therapy.

Authors:  Marcello Cocuzza; Ashok Agarwal
Journal:  Biologics       Date:  2007-09
  8 in total

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