Literature DB >> 6087338

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

A J Brake, J P Merryweather, D G Coit, U A Heberlein, F R Masiarz, G T Mullenbach, M S Urdea, P Valenzuela, P J Barr.   

Abstract

Saccharomyces cerevisiae cells were transformed with plasmids containing hybrid genes in which the sequence encoding mature human epidermal growth factor was joined to sequences encoding the leader region (preprosegment) of the precursor of the yeast mating pheromone alpha-factor. These cells accurately process the hybrid protein and efficiently secrete authentic biologically active human epidermal growth factor into the medium.

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Year:  1984        PMID： 6087338      PMCID： PMC391546          DOI： 10.1073/pnas.81.15.4642

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

Review 1.  Epidermal growth factor.

Authors:  G Carpenter; S Cohen
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Cloning of the yeast methionyl-tRNA synthetase gene.

Authors:  F Fasiolo; J Bonnet; F Lacroute
Journal:  J Biol Chem       Date:  1981-03-10       Impact factor: 5.157

4.  A protein sequenator.

Authors:  P Edman; G Begg
Journal:  Eur J Biochem       Date:  1967-03

5.  Transformation of yeast by a replicating hybrid plasmid.

Authors:  J D Beggs
Journal:  Nature       Date:  1978-09-14       Impact factor: 49.962

6.  Transformation of yeast.

Authors:  A Hinnen; J B Hicks; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

7.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688

8.  Stepwise cleavage of the pro part of promelittin by dipeptidylpeptidase IV. Evidence for a new type of precursor--product conversion.

Authors:  G Kreil; L Haiml; G Suchanek
Journal:  Eur J Biochem       Date:  1980-10

9.  Secretion of human interferons by yeast.

Authors:  R A Hitzeman; D W Leung; L J Perry; W J Kohr; H L Levine; D V Goeddel
Journal:  Science       Date:  1983-02-11       Impact factor: 47.728

10.  Human epidermal growth factor: isolation and chemical and biological properties.

Authors:  S Cohen; G Carpenter
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205
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  89 in total

1.  Cloning and secreted expression of the extracellular domain of the mumps virus fusion protein in Pichia pastoris.

Authors:  B McAleer; B Rima
Journal:  Virus Genes       Date:  2000       Impact factor: 2.332

2.  A single mutation in the activation site of bovine trypsinogen enhances its accumulation in the fermentation broth of the yeast Pichia pastoris.

Authors:  José Hanquier; Yannick Sorlet; Dominique Desplancq; Laurence Baroche; Marc Ebtinger; Jean-François Lefèvre; Franc Pattus; Charles L Hershberger; Alain A Vertès
Journal:  Appl Environ Microbiol       Date:  2003-02       Impact factor: 4.792

3.  Purification, characterization of GH11 endo-β-1,4-xylanase from thermotolerant Streptomyces sp. SWU10 and overexpression in Pichia pastoris KM71H.

Authors:  Warin Deesukon; Yuichi Nishimura; Tatsuji Sakamoto; Wasana Sukhumsirichart
Journal:  Mol Biotechnol       Date:  2013-05       Impact factor: 2.695

4.  Purification and characterization of recombinant tissue kallikrein from Escherichia coli and yeast.

Authors:  J Wang; J Chao; L Chao
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

5.  Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems.

Authors:  Tetsuya Harakuni; Hideki Sugawa; Ai Komesu; Masayuki Tadano; Takeshi Arakawa
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

6.  The CXXC motif: imperatives for the formation of native disulfide bonds in the cell.

Authors:  P T Chivers; M C Laboissière; R T Raines
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

Review 7.  Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells.

Authors:  Aleš Berlec; Borut Strukelj
Journal:  J Ind Microbiol Biotechnol       Date:  2013-02-06       Impact factor: 3.346

8.  Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

Authors:  M A Cantrell; D Anderson; D P Cerretti; V Price; K McKereghan; R J Tushinski; D Y Mochizuki; A Larsen; K Grabstein; S Gillis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

9.  Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.

Authors:  Peter Bernhardt; Elizabeth McCoy; Sarah E O'Connor
Journal:  Chem Biol       Date:  2007-08

10.  The effect of α-mating factor secretion signal mutations on recombinant protein expression in Pichia pastoris.

Authors:  Geoff P Lin-Cereghino; Carolyn M Stark; Daniel Kim; Jennifer Chang; Nadia Shaheen; Hansel Poerwanto; Kimiko Agari; Pachai Moua; Lauren K Low; Namphuong Tran; Amy D Huang; Maria Nattestad; Kristin T Oshiro; John William Chang; Archana Chavan; Jerry W Tsai; Joan Lin-Cereghino
Journal:  Gene       Date:  2013-02-21       Impact factor: 3.688
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