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Literature DB >> 6085275

The chemistry of enalapril.

Abstract

The design origins of the potent non-mercapto angiotensin converting enzyme inhibitors enalaprilat and its mono ethyl ester enalapril are described. Lactam analogues of enalaprilat have provided some insight into the conformation of this inhibitor when it is bound to converting enzyme. X-ray crystallographic studies of a related enzyme/inhibitor complex offer an explanation for the high potency and specificity of these and related inhibitors.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6085275 PMCID： PMC1463492 DOI： 10.1111/j.1365-2125.1984.tb02599.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

1. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.

Authors: D W Cushman; H S Cheung; E F Sabo; M A Ondetti
Journal: Biochemistry Date: 1977-12-13 Impact factor: 3.162

2. Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venom.

Authors: D W Cushman; J Pluscec; N J Williams; E R Weaver; E F Sabo; O Kocy; H S Cheung; M A Ondetti
Journal: Experientia Date: 1973-08-15

3. Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A.

Authors: L D Byers; R Wolfenden
Journal: Biochemistry Date: 1973-05-22 Impact factor: 3.162

4. A potent reversible inhibitor of carboxypeptidase A.

Authors: L D Byers; R Wolfenden
Journal: J Biol Chem Date: 1972-01-25 Impact factor: 5.157

5. Three new long-acting converting-enzyme inhibitors: relationship between plasma converting-enzyme activity and response to angiotensin I.

Authors: J Biollaz; M Burnier; G A Turini; D B Brunner; M Porchet; H J Gomez; K H Jones; F Ferber; W B Abrams; H Gavras; H R Brunner
Journal: Clin Pharmacol Ther Date: 1981-05 Impact factor: 6.875

6. A new class of angiotensin-converting enzyme inhibitors.

Authors: A A Patchett; E Harris; E W Tristram; M J Wyvratt; M T Wu; D Taub; E R Peterson; T J Ikeler; J ten Broeke; L G Payne; D L Ondeyka; E D Thorsett; W J Greenlee; N S Lohr; R D Hoffsommer; H Joshua; W V Ruyle; J W Rothrock; S D Aster; A L Maycock; F M Robinson; R Hirschmann; C S Sweet; E H Ulm; D M Gross; T C Vassil; C A Stone
Journal: Nature Date: 1980-11-20 Impact factor: 49.962

Review 7. Medical intelligence drug therapy: captopril.

Authors: D G Vidt; E L Bravo; F M Fouad
Journal: N Engl J Med Date: 1982-01-28 Impact factor: 91.245

8. Inhibition of thermolysin by N-carboxymethyl dipeptides.

Authors: A L Maycock; D M DeSousa; L G Payne; J ten Broeke; M T Wu; A A Patchett
Journal: Biochem Biophys Res Commun Date: 1981-10-15 Impact factor: 3.575

9. Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents.

Authors: M A Ondetti; B Rubin; D W Cushman
Journal: Science Date: 1977-04-22 Impact factor: 47.728

Review 10. Angiotensin-converting enzyme inhibitors: medicinal chemistry and biological actions.

Authors: E W Petrillo; M A Ondetti
Journal: Med Res Rev Date: 1982 Jan-Mar Impact factor: 12.944

6 in total

Review 1. Influence of dietary substances on intestinal drug metabolism and transport.

Authors: Christina S Won; Nicholas H Oberlies; Mary F Paine
Journal: Curr Drug Metab Date: 2010-11 Impact factor: 3.731

2. Evolution of diuretics and ACE inhibitors, their renal and antihypertensive actions--parallels and contrasts.

Authors: A F Lant
Journal: Br J Clin Pharmacol Date: 1987 Impact factor: 4.335

Review 3. Emerging trends in metalloprotein inhibition.

Authors: Matthieu Rouffet; Seth M Cohen
Journal: Dalton Trans Date: 2011-02-02 Impact factor: 4.390

Review 4. The chemistry of snake venom and its medicinal potential.

Authors: Ana L Oliveira; Matilde F Viegas; Saulo L da Silva; Andreimar M Soares; Maria J Ramos; Pedro A Fernandes
Journal: Nat Rev Chem Date: 2022-06-10 Impact factor: 34.571

Review 5. Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.

Authors: Christina S Won; Nicholas H Oberlies; Mary F Paine
Journal: Pharmacol Ther Date: 2012-08-04 Impact factor: 12.310

Review 6. Combination therapy with lercanidipine and enalapril in the management of the hypertensive patient: an update of the evidence.

Authors: Christina Antza; Stella Stabouli; Vasilios Kotsis
Journal: Vasc Health Risk Manag Date: 2016-11-15

6 in total