Literature DB >> 6084855

Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor.

Y Ashida, T Saijo, H Kuriki, H Makino, S Terao, Y Maki.   

Abstract

AA-861, a selective 5-lipoxygenase inhibitor, suppressed A23187-induced formations of 5-HETE and LTB4 in rat peritoneal macrophages. Immunologically-stimulated generation of SRS-A was also inhibited in guinea pig lung and rat peritoneal cavity. AA-861 had no effects on histamine release from rat mast cells or passive cutaneous anaphylaxis in rats. Essentially no antagonistic activity to LTD4 or histamine was observed. This compound exerted an obvious inhibition of allergic bronchoconstriction in guinea pigs and a moderate reduction of carrageenin-induced paw edema and pleurisy in rats. These findings suggest that SRS-A plays an important role in asthmatic and inflammatory reactions.

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Year:  1983        PMID： 6084855     DOI： 10.1016/0090-6980(83)90157-0

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  20 in total

1.  Adenosine A1-receptor stimulation of inositol phospholipid hydrolysis and calcium mobilisation in DDT1 MF-2 cells.

Authors:  T E White; J M Dickenson; S P Alexander; S J Hill
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739

2.  In vitro modulation of the eosinophil-dependent enhancement of the permeability of the bronchial mucosa.

Authors:  C A Herbert; D Edwards; J R Boot; C Robinson
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

3.  Ultraviolet radiation suppresses mouse-ear edema induced by topical application of arachidonic acid.

Authors:  K Danno; K Toda; K Ikai; T Horio; S Imamura
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

4.  Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice.

Authors:  M Ogata; T Matsumoto; M Kamochi; S I Yoshida; Y Mizuguchi; A Shigematsu
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

5.  Protective effects of a leukotriene inhibitor in an experimental massive hepatic cell necrosis model.

Authors:  Y Mizoguchi; Y Sakagami; S Seki; K Kobayashi; S Yamamoto; S Morisawa
Journal:  Gastroenterol Jpn       Date:  1988-06

6.  Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.

Authors:  Ann M Gregus; Darren S Dumlao; Spencer C Wei; Paul C Norris; Laura C Catella; Flore G Meyerstein; Matthew W Buczynski; Joanne J Steinauer; Bethany L Fitzsimmons; Tony L Yaksh; Edward A Dennis
Journal:  FASEB J       Date:  2013-02-04       Impact factor: 5.191

7.  Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.

Authors:  Hsiang-Chin Chen; Jia Xie; Zheng Zhang; Li-Ting Su; Lixia Yue; Loren W Runnels
Journal:  PLoS One       Date:  2010-06-17       Impact factor: 3.240

8.  In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis.

Authors:  R Fruchtmann; K H Mohrs; A Hatzelmann; S Raddatz; B Fugmann; B Junge; H Horstmann; R Müller-Peddinghaus
Journal:  Agents Actions       Date:  1993-03

9.  Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea.

Authors:  A Da Silva; Y Amrani; A Trifilieff; Y Landry
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

10.  Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2.

Authors:  A Miyake; H Yamamoto; E Kubota; K Hamaguchi; A Kouda; K Honda; H Kawashima
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739
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