Literature DB >> 6084476

The disappearance rate of pregnancy-associated plasma protein-A (PAPP-A) after the end of normal and abnormal pregnancies.

P Bischof, M Amandruz, C Weil-Franck, J P Baeriswyl, A Weil, W L Hermann, P C Sizonenko.   

Abstract

PAPP-A is a macromolecular glycoprotein associated with human pregnancy. In vitro, PAPP-A is produced by explant cultures of trophoblast and decidua. The present work was undertaken to see if the presence of decidua had any effect on the disappearance rate of PAPP-A after removal of the placenta either by surgery or by spontaneous delivery. PAPP-A was measured before and at different times after a normal delivery (n = 6), after a termination of early pregnancy (n = 11) and after surgery for ectopic pregnancy (n = 8). The half life of PAPP-A after normal delivery (52.9 +/- 25.8 h, SD) was significantly (p less than 0.03) less than after a first trimester termination (93.9 +/- 41.6 h). After surgery for ectopic pregnancy in patients with curetted decidua, PAPP-A disappeared significantly faster (p less than 0.005) then in patients with intact decidua (84.1 +/- 17.8 vs 241.2 +/- 81.5 h). These results indicate that PAPP-A continues to be produced by the decidua after removal of the trophoblast in early pregnancy.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6084476     DOI： 10.1007/bf02134005

Source DB:  PubMed          Journal:  Arch Gynecol        ISSN： 0170-9925


  13 in total

1.  Pregnancy-associated plasma protein A: circulating levels during normal pregnancy.

Authors:  J Folkersen; J G Grudzinskas; P Hindersson; B Teisner; J G Westergaard
Journal:  Am J Obstet Gynecol       Date:  1981-04-15       Impact factor: 8.661

2.  Three pregnancy-associated human plasma proteins: purification, monospecific antisera and immunological indentification.

Authors:  T M Lin; S P Halbert; D Kiefer; W N Spellacy
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

3.  Studies on human pregnancy-associated plasma protein A. Purification by affinity chromatography and structural comparisons with alpha 2-macroglobulin.

Authors:  R G Sutcliffe; B M Kukulska-Langlands; J R Coggins; J B Hunter; C H Gore
Journal:  Biochem J       Date:  1980-12-01       Impact factor: 3.857

4.  Radioimmunoassay for the measurement of pregnancy-associated plasma protein-A (PAPP-A) in humans.

Authors:  P Bischof; L Haenggeli; M T Sizonenko; W Herrmann; P C Sizonenko
Journal:  Biol Reprod       Date:  1981-06       Impact factor: 4.285

5.  Tissue and plasma concentrations of pregnancy-associated plasma protein-A (PAPP-A): comparison with other fetoplacental products.

Authors:  S Duberg; P Bischof; A M Schindler; F Béguin; W Herrmann; P C Sizonenko
Journal:  Br J Obstet Gynaecol       Date:  1982-05

6.  Is pregnancy-associated plasma protein A a tumor marker?

Authors:  P Bischof; C H Rapin; A Weil; W Herrmann
Journal:  Am J Obstet Gynecol       Date:  1982-06-15       Impact factor: 8.661

7.  In vitro production of pregnancy-associated plasma protein A by human decidua and trophoblast.

Authors:  P Bischof; S DuBerg; M T Sizonenko; A M Schindler; F Béguin; W L Herrmann; P C Sizonenko
Journal:  Am J Obstet Gynecol       Date:  1984-01-01       Impact factor: 8.661

8.  Pregnancy-associated plasma protein-A (PAPP-A) inhibits thrombin-induced coagulation of plasma.

Authors:  P Bischof; A Meisser; L Haenggeli; G Reber; C Bouvier; F Béguin; W L Herrmann; P C Sizonenko
Journal:  Thromb Res       Date:  1983-10-01       Impact factor: 3.944

9.  Pregnancy-associated plasma protein A (PAPP-A) specifically inhibits the third component of human complement (C3).

Authors:  P Bischof; A Geinoz; W L Herrmann; P C Sizonenko
Journal:  Placenta       Date:  1984 Jan-Feb       Impact factor: 3.481

10.  Purification and characterization of pregnancy associated plasma protein A (PAPP-A).

Authors:  P Bischof
Journal:  Arch Gynecol       Date:  1979
View more
  3 in total

1.  Progesterone dependence and extratrophoblastic origin of pregnancy-associated plasma protein-A (PAPP-A) in early pregnancy.

Authors:  P Bischof; A M Schindler; R Wyss; W L Herrmann; P C Sizonenko
Journal:  Arch Gynecol       Date:  1986

Review 2.  First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome.

Authors:  S Shiefa; M Amargandhi; J Bhupendra; S Moulali; T Kristine
Journal:  Indian J Clin Biochem       Date:  2012-10-12

3.  PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans.

Authors:  Raziel Rojas-Rodriguez; Rachel Ziegler; Tiffany DeSouza; Sana Majid; Aylin S Madore; Nili Amir; Veronica A Pace; Daniel Nachreiner; David Alfego; Jomol Mathew; Katherine Leung; Tiffany A Moore Simas; Silvia Corvera
Journal:  Sci Transl Med       Date:  2020-11-25       Impact factor: 17.956
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.