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Literature DB >> 6084226

Choroidal neovascularization can digest Bruch's membrane. A prior break is not essential.

W J Heriot, P Henkind, R W Bellhorn, M S Burns.

Abstract

A novel form of retinal phototoxicity has facilitated investigation of the effect of retinal pigment epithelial (RPE) damage on the choriocapillaris of the rat. In response to isolated RPE injury, the choriocapillaris buds, digests the endothelial basement membrane, and projects pseudopodia that erode Bruch's membrane. The development of subretinal neovascularization in one of the rats demonstrates that breaks in Bruch's membrane may result from this lytic process and that neither degeneration of Bruch's membrane nor a preexisting break is essential for subretinal neovascularization to occur.

Entities: Disease Species

Mesh：

Substances：
Peptide Hydrolases

Year: 1984 PMID： 6084226 DOI： 10.1016/s0161-6420(84)34112-4

Source DB: PubMed Journal: Ophthalmology ISSN： 0161-6420 Impact factor: 12.079

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Cited

16 in total

1. Influence of laser photocoagulation on choroidal capillary cytoarchitecture.

Authors: R H Guymer; G S Hageman; A C Bird
Journal: Br J Ophthalmol Date: 2001-01 Impact factor: 4.638

2. Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study.

Authors: Abbas Shirinifard; James Alexander Glazier; Maciej Swat; J Scott Gens; Fereydoon Family; Yi Jiang; Hans E Grossniklaus
Journal: PLoS Comput Biol Date: 2012-05-03 Impact factor: 4.475

3. Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis.

Authors: P L Penfold; J M Provis; F A Billson
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1987 Impact factor: 3.117

4. Rheological studies on patients with posterior subretinal neovascularization and exudative age-related macular degeneration.

Authors: W Inhoffen; Z Nüssgens
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1990 Impact factor: 3.117

10. Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy.

Authors: M Matsuoka; N Ogata; T Otsuji; T Nishimura; K Takahashi; M Matsumura
Journal: Br J Ophthalmol Date: 2004-06 Impact factor: 4.638

Choroidal neovascularization can digest Bruch's membrane. A prior break is not essential.

1. Influence of laser photocoagulation on choroidal capillary cytoarchitecture.

2. Adhesion failures determine the pattern of choroidal neovascularization in the eye: a computer simulation study.

3. Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis.

4. Rheological studies on patients with posterior subretinal neovascularization and exudative age-related macular degeneration.

5. Experimental subretinal neovascularization in the rabbit.

6. Prostate-specific membrane antigen is undetectable in choroidal neovascular membrane.

7. Basal linear deposit in the human macula.

8. Pigment epithelial repair.

9. Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study.

10. Expression of pigment epithelium derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy.