Literature DB >> 2436980

Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis.

P L Penfold, J M Provis, F A Billson.   

Abstract

We describe the ultrastructural features of subretinal neovascularisation associated with the pathogenesis of age-related macular degeneration (AMD). The choroidal origin of new vessels was confirmed, and ultrastructural details are presented. Serial sectioning of new vessels revealed a relationship between leucocytes and neovascular structures. The results are discussed in the context of the previously established role of leucocytes in angiogenesis. Our results provide circumstantial evidence, based on morphological observations, for the involvement of leucocytes in the promotion of neovascular proliferation and exudation from new vessels.

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Year:  1987        PMID： 2436980     DOI： 10.1007/bf02155808

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  20 in total

Review 1.  The development of an experimental model of subretinal neovascularization in disciform macular degeneration.

Authors:  S J Ryan
Journal:  Trans Am Ophthalmol Soc       Date:  1979

2.  Development and ultrastructure of peripheral subretinal neovascularizations.

Authors:  M Spitznas; N Bornfeld
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1978-11-08

3.  The ultrastructure of lymphocytes.

Authors:  D Zucker-Franklin
Journal:  Semin Hematol       Date:  1969-01       Impact factor: 3.851

4.  Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium.

Authors:  P L Penfold; M C Killingsworth; S H Sarks
Journal:  Invest Ophthalmol Vis Sci       Date:  1986-03       Impact factor: 4.799

5.  Electron microscopic features of experimental choroidal neovascularization.

Authors:  D B Archer; T A Gardiner
Journal:  Am J Ophthalmol       Date:  1981-04       Impact factor: 5.258

6.  Modulation of endothelial cell morphology and collagen synthesis by polymorphonuclear leukocytes.

Authors:  E P Kay; M E Nimni; R E Smith
Journal:  Invest Ophthalmol Vis Sci       Date:  1984-05       Impact factor: 4.799

7.  Basement membrane collagen: degradation by migrating endothelial cells.

Authors:  T Kalebic; S Garbisa; B Glaser; L A Liotta
Journal:  Science       Date:  1983-07-15       Impact factor: 47.728

8.  Softening of drusen and subretinal neovascularization.

Authors:  S H Sarks; D Van Driel; L Maxwell; M Killingsworth
Journal:  Trans Ophthalmol Soc U K       Date:  1980-09

9.  An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. II. Studies on the effect of leukocytic elimination on corneal vascularization.

Authors:  C H Fromer; G K Klintworth
Journal:  Am J Pathol       Date:  1975-12       Impact factor: 4.307

Review 10.  Senile macular degeneration: review of epidemiologic features.

Authors:  F L Ferris
Journal:  Am J Epidemiol       Date:  1983-08       Impact factor: 4.897
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  38 in total

1.  Serum levels of antioxidants and age-related macular degeneration.

Authors:  N C Tsang; P L Penfold; P J Snitch; F Billson
Journal:  Doc Ophthalmol       Date:  1992       Impact factor: 2.379

2.  Symmetry of disciform scars in bilateral age-related macular degeneration.

Authors:  M J Lavin; B Eldem; Z J Gregor
Journal:  Br J Ophthalmol       Date:  1991-03       Impact factor: 4.638

Review 3.  Mediators of ocular angiogenesis.

Authors:  Yureeda Qazi; Surekha Maddula; Balamurali K Ambati
Journal:  J Genet       Date:  2009-12       Impact factor: 1.166

4.  Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat.

Authors:  W Y Shen; M J Yu; C J Barry; I J Constable; P E Rakoczy
Journal:  Br J Ophthalmol       Date:  1998-09       Impact factor: 4.638

5.  Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change.

Authors:  Anil Kumar; Lian Zhao; Robert N Fariss; Paul G McMenamin; Wai T Wong
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-25       Impact factor: 4.799

6.  Choroidal neovascularisation in age-related macular disease.

Authors:  A C Bird
Journal:  Br J Ophthalmol       Date:  1993-10       Impact factor: 4.638

7.  Clinicopathological correlation of primary and recurrent choroidal neovascularisation following surgical excision in age related macular degeneration.

Authors:  A A Castellarin; M A Nasir; I K Sugino; M A Zarbin
Journal:  Br J Ophthalmol       Date:  1998-05       Impact factor: 4.638

8.  Autoantibodies to retinal astrocytes associated with age-related macular degeneration.

Authors:  P L Penfold; J M Provis; J H Furby; P A Gatenby; F A Billson
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1990       Impact factor: 3.117

9.  Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration.

Authors:  Robert F Mullins; Elizabeth A Faidley; Heather T Daggett; Catherine Jomary; Andrew J Lotery; Edwin M Stone
Journal:  Exp Eye Res       Date:  2009-07-14       Impact factor: 3.467

10.  Pro-angiogenic effect of IFNgamma is dependent on the PI3K/mTOR/translational pathway in human retinal pigmented epithelial cells.

Authors:  Baoying Liu; Lisa Faia; Mengjun Hu; Robert B Nussenblatt
Journal:  Mol Vis       Date:  2010-02-10       Impact factor: 2.367
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