Literature DB >> 4260277

Enduring behavioral changes in rats with experimental phenylketonuria.

A E Andersen, G Guroff.   

Abstract

Several criticisms of past attempts to produce experimental phenylketonuria are discussed, and a model that appears to meet these criticisms is presented. This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood. By this method, an experimental subject is produced whose behavioral, neurological, and biochemical characteristics are similar to those of clinical patients with phenylketonuria.

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Year:  1972        PMID： 4260277      PMCID： PMC426582          DOI： 10.1073/pnas.69.4.863

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Behavioral, biochemical and maturation effects of early DL-para-chlorophenylalanine treatment.

Authors:  M M Kilbey; R T Harris
Journal:  Psychopharmacologia       Date:  1971

2.  Influence of malnutrition in early life on exploratory behavior of rats.

Authors:  S Franková; R H Barnes
Journal:  J Nutr       Date:  1968-12       Impact factor: 4.798

Review 3.  The pathogenesis of mental retardation in phenylketonuria and other inborn errors of amino acid metabolism.

Authors:  J H Menkes
Journal:  Pediatrics       Date:  1967-02       Impact factor: 7.124

4.  Use of p-chlorophenylalanine to induce a phenylketonuric-like condition in rats.

Authors:  G T Pryor; C Mitoma
Journal:  Neuropharmacology       Date:  1970-05       Impact factor: 5.250

5.  Increased cerebral excitability caused by p-chlorophenylalanine in young rats.

Authors:  J W Prichard; G Guroff
Journal:  J Neurochem       Date:  1971-01       Impact factor: 5.372

6.  Ocular studies with para-chlorophenylalanine in rats and monkeys.

Authors:  E J Gralla; L Rubin
Journal:  Arch Ophthalmol       Date:  1970-06

7.  Neuropathology of phenylketonuria.

Authors:  N Malamud
Journal:  J Neuropathol Exp Neurol       Date:  1966-04       Impact factor: 3.685

8.  Dosage parameters of a behavioral deficit associated with phenylketonuria in rats.

Authors:  V J Polidora; R F Cunningham; H A Waisman
Journal:  J Comp Physiol Psychol       Date:  1966-06

9.  The effect of undernutrition and subsequent rehabilitation on the growth and composition of the central nervous system of the rat.

Authors:  J W Dickerson; A L Walmsley
Journal:  Brain       Date:  1967-12       Impact factor: 13.501

10.  p-Chlorophenylalanine-induced chemical manifestations of phenylketonuria in rats.

Authors:  M A Lipton; R Gordon; G Guroff; S Udenfriend
Journal:  Science       Date:  1967-04-14       Impact factor: 47.728
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  8 in total

1.  Chronic postnatal ornithine administration to rats provokes learning deficit in the open field task.

Authors:  Carolina Maso Viegas; Estela Natacha Brandt Busanello; Anelise Miotti Tonin; Mateus Grings; Alana Pimentel Moura; Luciana Ritter; Angela Zanatta; Lisiane Aurélio Knebel; Vannessa Araujo Lobato; Letícia Ferreira Pettenuzzo; Carmen Regla Vargas; Guilhian Leipnitz; Moacir Wajner
Journal:  Metab Brain Dis       Date:  2012-06-16       Impact factor: 3.584

2.  Egg and breast milk based nitrogen sources compared.

Authors:  J W Puntis; P A Ball; M A Preece; A Green; G A Brown; I W Booth
Journal:  Arch Dis Child       Date:  1989-10       Impact factor: 3.791

3.  Aromatic acids derived from phenylalanine in the tissues of rats with experimentally induced phenylketonuria-like characteristics.

Authors:  D J Edwards; K Blau
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

4.  The enduring behavioral changes in rats with experimental phenylketonuria.

Authors:  A E Andersen; V Rowe; G Guroff
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

5.  Phenylketonuria: clinical and experimental considerations revealed by the use of animal models.

Authors:  J D Lane; V Neuhoff
Journal:  Naturwissenschaften       Date:  1980-05

6.  Comparison of alpha-methylphenylalanine and p-chlorophenylalanine as inducers of chronic hyperphenylalaninaemia in developing rats.

Authors:  J A Delvalle; G Dienel; O Greengard
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

7.  Outcome of pregnancy in the rat with mild hyperphenylalaninaemia and hypertyrosinaemia: implications for the management of "human maternal PKU".

Authors:  S A Lewis; I C Lyon; R B Elliott
Journal:  J Inherit Metab Dis       Date:  1985       Impact factor: 4.982

8.  The regulation of phenylalanine hydroxylase in rat tissues in vivo. The maintenance of high plasma phenylalanine concentrations in suckling rats: a model for phenylketonuria.

Authors:  J A Delvalle; O Greengard
Journal:  Biochem J       Date:  1976-03-15       Impact factor: 3.857
  8 in total

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