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Literature DB >> 606259

Lysosomes and membrane recycling. A hypothesis.

Abstract

A mechanism for intralysosomal membrane recycling is proposed. After invagination of the lysosomal membrane during autophagy, intralysosomal vesicles are formed. It is suggested that membrane can bleb out from these internal vesicles, probably in the form of very small vesicles, and return to the external lysosomal membrane by membrane fusion. This mechanism would conserve lysosomal membrane during autophay, and is analogous to current models of plasma-membrane recycling. Its relationship to turnover of lysosomal-membrane proteins and other proteins is discussed.

Mesh：

Year: 1977 PMID： 606259 PMCID： PMC1183815 DOI： 10.1042/bj1680603

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes.

Authors: R T Dean
Journal: Biochem Biophys Res Commun Date: 1975-11-17 Impact factor: 3.575

Review 2. Lysosomes.

Authors: R T Dean; A J Barrett
Journal: Essays Biochem Date: 1976 Impact factor: 8.000

7. Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

Authors: J M Backer; J F Dice
Journal: Proc Natl Acad Sci U S A Date: 1986-08 Impact factor: 11.205

8. Characterization of the membrane proteins of rat liver lysosomes. Composition, enzyme activities and turnover.

Authors: J Burnside; D L Schneider
Journal: Biochem J Date: 1982-05-15 Impact factor: 3.857

9. Retrieval of lysosomal membrane and acid phosphatase from phagolysosomes of Paramecium caudatum.

Authors: R D Allen; A K Fok
Journal: J Cell Biol Date: 1984-12 Impact factor: 10.539

9 in total

Lysosomes and membrane recycling. A hypothesis.

1. Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes.

Review 2. Lysosomes.

3. Lymphokine-induced production and release of lysosomal enzymes by macrophages.

4. Membrane economics in endocytic systems.

5. A sensitive assay for cellular hypersensitivity based on the uptake of radioactive colloidal gold.

6. Exocytosis-endocytosis coupling in the pancreatic beta cell.

Review 7. Mechanism and regulation of protein turnover in animal cells.

8. Membrane structure: some general principles.

9. Membrane flow during pinocytosis. A stereologic analysis.

10. Potassium and amino acid transport in human leukocytes exposed to phagocytic stimuli.

Review 1. Alternative pathways for MHC class I presentation: a new function for autophagy.

Review 2. Extrahepatic cell membrane lipid abnormalities and cellular dysfunction in liver disease.

Review 3. Autophagy and lysosomal proteolysis in the liver.

Review 4. Lysosomes and the connective tissue diseases.

5. Effects of weak bases on the degradation of endogenous and exogenous proteins by rat yolk sacs.

6. Changes in acid phosphatase activity in rat liver after ischemia.

7. Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

8. Characterization of the membrane proteins of rat liver lysosomes. Composition, enzyme activities and turnover.

9. Retrieval of lysosomal membrane and acid phosphatase from phagolysosomes of Paramecium caudatum.