Literature DB >> 6058346

Antihemophilic factor release by perfused liver and spleen: relationship to hemophilia.

J C Norman, J P Lambilliotte, Y Kojima, H S Sise.   

Abstract

As judged by perfusion of isolated organs an antihemophilic factor is produced in the liver and the spleen. Perfusates (from hemophiliacs) that are deficient in the human anti-hemophilic factor stimulate production of the factor during perfusion. Apparently there is an antihemophilic-factor-stimulating substance in the plasma of hemophiliacs. The data suggest that splenic homotransplantation might alleviate the symptoms of hemophilia.

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Year:  1967        PMID: 6058346     DOI: 10.1126/science.158.3804.1060

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  5 in total

1.  Organ transplant for haemophilia.

Authors: 
Journal:  Br Med J       Date:  1969-05-24

2.  Attempted spleen transplant in classical hemophilia.

Authors:  W E Hathaway; M M Mull; J H Githens; C G Groth; T L Marchioro; T E Starzl
Journal:  Transplantation       Date:  1969-01       Impact factor: 4.939

3.  Synthesis of antihemophilic factor antigen by cultured human endothelial cells.

Authors:  E A Jaffe; L W Hoyer; R L Nachman
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

4.  Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy.

Authors:  L W Hoyer; R P De los Santos; J R Hoyer
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

5.  Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A.

Authors:  F R Rickles; J A Hardin; F A Pitlick; L W Hoyer; M E Conrad
Journal:  J Clin Invest       Date:  1973-06       Impact factor: 14.808

  5 in total

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