Literature DB >> 4634046

Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A.

F R Rickles, J A Hardin, F A Pitlick, L W Hoyer, M E Conrad.   

Abstract

The procoagulant material of lymphocytes has been characterized as tissue factor. Lymphocytes stimulated with phytohemagglutinin or the purified protein derivative of the tubercle bacillus developed procoagulant activity with incubation in tissue culture. While this material corrected the prolonged clotting time of factor VIII (AHF) deficient plasma, we have shown, utilizing a sensitive radioimmunoassay, that no AHF antigen was present in the cell cultures. Further, we have demonstrated this material to be tissue factor by coagulation techniques and immunological cross-reactivity. The published data regarding factor VIII synthesis is reviewed in light of these observations and comments are made regarding the role of the lymphocyte procoagulant.

Entities:  

Mesh：

Substances：

Year:  1973        PMID： 4634046      PMCID： PMC302407          DOI： 10.1172/JCI107316

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  44 in total

1.  The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies.

Authors:  R R PROCTOR; S I RAPAPORT
Journal:  Am J Clin Pathol       Date:  1961-09       Impact factor: 2.493

2.  Antihaemophilic globulin (AHG) in multiple myeloma and macroglobulinaemia.

Authors:  H J Weiss; S Kochwa
Journal:  Br J Haematol       Date:  1968-02       Impact factor: 6.998

3.  Transplantation of the spleen.

Authors:  J C Norman; W H Covelli; H S Sise
Journal:  Ann Intern Med       Date:  1968-03       Impact factor: 25.391

4.  The role of protein synthesis on the generation of tissue factor activity by leukocytes.

Authors:  J Niemetz; V Herbert
Journal:  Proc Soc Exp Biol Med       Date:  1972-04

5.  Attempted spleen transplant in classical hemophilia.

Authors:  W E Hathaway; M M Mull; J H Githens; C G Groth; T L Marchioro; T E Starzl
Journal:  Transplantation       Date:  1969-01       Impact factor: 4.939

6.  Endotoxin-induced intravascular clotting: the need for granulocytes.

Authors:  R G Lerner; S I Rapaport; J M Spitzer
Journal:  Thromb Diath Haemorrh       Date:  1968-12-31

7.  Cell-culture synthesis of a factor VIII-like activity.

Authors:  L R Zacharski; E J Bowie; J L Titus; C A Owen
Journal:  Mayo Clin Proc       Date:  1969-11       Impact factor: 7.616

8.  Immunologic studies of antihemophilic factor (AHF, factor VIII). IV. Radioimmunoassay of AHF antigen.

Authors:  L W Hoyer
Journal:  J Lab Clin Med       Date:  1972-12

9.  Antihemophilic factor release by perfused liver and spleen: relationship to hemophilia.

Authors:  J C Norman; J P Lambilliotte; Y Kojima; H S Sise
Journal:  Science       Date:  1967-11       Impact factor: 47.728

10.  Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

Authors:  T S Zimmerman; O D Ratnoff; A E Powell
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808
View more
  32 in total

1.  The effects of epinephrine infusion in patients with von Willebrand's disease.

Authors:  F R Rickles; L W Hoyer; M E Rick; D J Ahr
Journal:  J Clin Invest       Date:  1976-06       Impact factor: 14.808

2.  Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes.

Authors:  H Rothberger; T S Zimmerman; H L Spiegelberg; J H Vaughan
Journal:  J Clin Invest       Date:  1977-03       Impact factor: 14.808

3.  Antigen-induced monocyte procoagulant activity. Requirement for antigen presentation and histocompatibility leukocyte antigen-DR molecules.

Authors:  B S Schwartz
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808

4.  Concanavalin A inhibits tissue factor coagulant activity.

Authors:  F A Pitlick
Journal:  J Clin Invest       Date:  1975-01       Impact factor: 14.808

5.  The stimulatory effect of platelets and platelet membranes on the procoagulant activity of leukocytes.

Authors:  J Niemetz; A J Marcus
Journal:  J Clin Invest       Date:  1974-12       Impact factor: 14.808

6.  Correction of coagulation in the hemophilic dog by transplantation of lymphatic tissue.

Authors:  C G Groth; W E Hathaway; A Gustafsson; W P Geis; C W Putnam; C Björkén; K A Porter; T E Starzl
Journal:  Surgery       Date:  1974-05       Impact factor: 3.982

7.  The procoagulant activity of human granulocytes, lymphocytes and monocytes stimulated by endotoxin. Coagulation and electron microscopic studies.

Authors:  E Hiller; J G Saal; P Ostendorf; G W Griffiths
Journal:  Klin Wochenschr       Date:  1977-08-01

8.  Structural features of Salmonella typhimurium lipopolysaccharide required for activation of tissue factor in human mononuclear cells.

Authors:  F R Rickles; P D Rick
Journal:  J Clin Invest       Date:  1977-06       Impact factor: 14.808

9.  In situ characterization of antigenic and functional tissue factor expression in human tumors utilizing monoclonal antibodies and recombinant factor VIIa as probes.

Authors:  J Contrino; G A Hair; M A Schmeizl; F R Rickles; D L Kreutzer
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

10.  Delayed-type hypersensitivity skin reactions in congenital afibrinogenemia lack fibrin deposition and induration.

Authors:  R B Colvin; M W Mosesson; H F Dvorak
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.