Literature DB >> 604362

An enzyme inhibition assay for 2,4-diamino-5-(3'4'-dichlorophenyl)-6-methylpyrimidine (DDMP,NSC 19494).

A H Calvert, J S Cridland, K R Harrap.   

Abstract

An enzyme inhibiton method for the determination of serum levels of DDMP is described. This has proved to be a simple, practical, and reliable method for the clinical monitoring of patients.

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Year:  1977        PMID： 604362      PMCID： PMC476700          DOI： 10.1136/jcp.30.12.1154

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  9 in total

1.  Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases.

Authors:  R C Jackson; L I Hart; K R Harrap
Journal:  Cancer Res       Date:  1976-06       Impact factor: 12.701

Review 2.  TECHNIQUES FOR STUDY OF RESISTANCE TO FOLIC ACID ANTAGONISTS.

Authors:  J R BERTINO; G A FISCHER
Journal:  Methods Med Res       Date:  1964

3.  Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.

Authors:  M L MURPHY; R R ELLISON; D A KARNOFSKY; J H BURCHENAL
Journal:  J Clin Invest       Date:  1954-10       Impact factor: 14.808

4.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

5.  Methodichlorophen as anti-tumor drug.

Authors:  L A Price; J H Goldie; B T Hill
Journal:  Br Med J       Date:  1975-04-05

6.  Determination of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (BW 197U) in human plasma.

Authors:  J S Cridland; B C Weatherley
Journal:  J Chromatogr       Date:  1977-07-21

7.  Quantitation of pyrimethamine and related diaminopyrimidines in situ by enhancement of fluorescence after thin layer chromatography.

Authors:  W S Simmons; R L DeAngelis
Journal:  Anal Chem       Date:  1973-07       Impact factor: 6.986

8.  Dihydrofolate reductase from Trypanosoma equiperdum. II. Inhibition by 2,4-diaminopyrimidines and related heterocycles.

Authors:  J J McCormack; J J Jaffe
Journal:  J Med Chem       Date:  1969-07       Impact factor: 7.446

9.  Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.

Authors:  B T Hill; J H Goldie; L A Price
Journal:  Br J Cancer       Date:  1973-09       Impact factor: 7.640
  9 in total
  1 in total

1.  Kinetics of metoprine, a lipid-soluble antifolate.

Authors:  B R Jones; C S Gordon; J Umans; M M Reidenberg; C W Young
Journal:  Br J Clin Pharmacol       Date:  1981-11       Impact factor: 4.335
  1 in total

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