Literature DB >> 165854

Methodichlorophen as anti-tumor drug.

L A Price, J H Goldie, B T Hill.   

Abstract

Methodichlorophen was given to 26 patients with terminal malignant disease. Eight patients received adequate doses, and five of them showed objective evidence of tumour regression while three failed to respond. Those who responded included four out of five patients with lung cancer (three with squamous-cell carcinoma and one with oat-cell carcinoma) and a patient with hypernephroma. Two patients with testicular teratomas and one with acute myeloid leukemia failed to respond. The drug may be given safely by mouth to outpatients if certain precautions are taken.

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Year:  1975        PMID: 165854      PMCID: PMC1672937          DOI: 10.1136/bmj.2.5961.20

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  5 in total

1.  Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.

Authors:  M L MURPHY; R R ELLISON; D A KARNOFSKY; J H BURCHENAL
Journal:  J Clin Invest       Date:  1954-10       Impact factor: 14.808

2.  Effect of various compounds on the Ehrlich ascites carcinoma.

Authors:  K SUGIURA
Journal:  Cancer Res       Date:  1953-06       Impact factor: 12.701

3.  Studies on the transport and distribution of diaminopyrimidines in L5178Y lymphoblasts in cell culture.

Authors:  B T Hill; L A Price; S I Harrison; J H Goldie
Journal:  Biochem Pharmacol       Date:  1975-02-15       Impact factor: 5.858

4.  Treatment of meningeal leukemia with pyrimethamine.

Authors:  G F Geils; C W Scott; C M Baugh
Journal:  Blood       Date:  1971-08       Impact factor: 22.113

5.  Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.

Authors:  B T Hill; J H Goldie; L A Price
Journal:  Br J Cancer       Date:  1973-09       Impact factor: 7.640

  5 in total
  7 in total

Review 1.  New cancer chemotherapy drugs in Europe.

Authors:  G Mathé; L M van Putten
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

2.  An enzyme inhibition assay for 2,4-diamino-5-(3'4'-dichlorophenyl)-6-methylpyrimidine (DDMP,NSC 19494).

Authors:  A H Calvert; J S Cridland; K R Harrap
Journal:  J Clin Pathol       Date:  1977-12       Impact factor: 3.411

3.  Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid.

Authors:  P Alberto; R Peytremann; R Medenica; M Beretta-Piccoli
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

4.  Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).

Authors:  R de Jager; D Dupont; J J Rodzynek; C Dorlet; G Lagrange
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

5.  Phase II clinical trial of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine) and folinic acid (CF) in solid tumors.

Authors:  R de Jager; A Brugarolas; M Hansen
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

6.  Kinetics of metoprine, a lipid-soluble antifolate.

Authors:  B R Jones; C S Gordon; J Umans; M M Reidenberg; C W Young
Journal:  Br J Clin Pharmacol       Date:  1981-11       Impact factor: 4.335

7.  Cross resistance to esters of methotrexate in a doxorubicin-resistant subline of P388 murine leukemia.

Authors:  A Ramu; M Fridkin; R Steinherz
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

  7 in total

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