Literature DB >> 603637

Phosphorus nuclear-magnetic-resonance studies of the transition-state analogue complex of creatine kinase.

E J Milner-White, D S Rycroft.   

Abstract

31P nuclear-magnetic-resonance spectra of MgADP bound to creatine kinase in the presence of creatine NO3- ions show that there are two non-identical forms of the bound nucleotide. The sites have different affinities for the nucleotide. MgADP at the high-affinity site is in slow exchange (k less than 125s-1 at 27 degrees C) with free MgADP.

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Year:  1977        PMID： 603637      PMCID： PMC1183731          DOI： 10.1042/bj1670827

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

Review 1.  Transition state analog inhibitors and enzyme catalysis.

Authors:  R Wolfenden
Journal:  Annu Rev Biophys Bioeng       Date:  1976

2.  31P nuclear magnetic resonance of bound substrates of arginine kinase reaction: chemical shifts in binary, ternary, quaternary, and transition state analog complexes.

Authors:  B D Rao; M Cohn
Journal:  J Biol Chem       Date:  1977-05-25       Impact factor: 5.157

3.  Non-identical behaviour of the subunits of rabbit muscule creatine kinase.

Authors:  N C Price; M G Hunter
Journal:  Biochim Biophys Acta       Date:  1976-09-14

4.  The interaction of 8-anilino-1-naphthalenesulfonate with creatine kinase. Evidence for cooperativitiy of nucleotide binding.

Authors:  A C McLaughlin
Journal:  J Biol Chem       Date:  1974-03-10       Impact factor: 5.157

5.  Inhibition of adenosine 5'-triphosphate-creatine phosphotransferase by substrate-anion complexes. Evidence for the transition-state organization of the catalytic site.

Authors:  E J Milner-White; D C Watts
Journal:  Biochem J       Date:  1971-05       Impact factor: 3.857

6.  Thermodynamic studies of the formation and ionization of the magnesium(II) complexes of ADP and ATP over the pH range 5 to 9.

Authors:  R C Phillips; P George; R J Rutman
Journal:  J Am Chem Soc       Date:  1966-06-20       Impact factor: 15.419

7.  Creatine kinase. Modification of the working enzyme.

Authors:  E J Milner-White; I D Kelly
Journal:  Biochem J       Date:  1976-07-01       Impact factor: 3.857

8.  Binding of adenosine 5'-diphosphate to creatine kinase. An investigation using intermolecular nuclear Overhauser effect measurements.

Authors:  T L James
Journal:  Biochemistry       Date:  1976-10-19       Impact factor: 3.162

9.  Heterogeneity of rabbit muscle creatine kinase and limited proteolysis by proteinase K.

Authors:  J Williamson; J Greene; S Chérif; E J Milner-White
Journal:  Biochem J       Date:  1977-12-01       Impact factor: 3.857

10.  31P NMR studies of the arginine kinase reaction. Equilibrium constants and exchange rates at stoichiometric enzyme concentration.

Authors:  B D Rao; D H Buttlaire; M Cohn
Journal:  J Biol Chem       Date:  1976-11-25       Impact factor: 5.157
  10 in total

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