Literature DB >> 6025544

Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside.

D Kessel, T C Hall, I Wodinsky.   

Abstract

Survival of mice bearing different transplantable leukemias and treated with cytosine arabinoside was compared with uptake and subsequent phosphorylation of the drug in vitro. Capacity for nucleotide formation was correlated with response and is apparently an important determinant of drug sensitivity. Drug uptake, although apparently mediated, was similar in all cell lines.

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Year:  1967        PMID： 6025544     DOI： 10.1126/science.156.3779.1240

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Pharmacogenomics in pediatric leukemia.

Authors:  Steven W Paugh; Gabriele Stocco; William E Evans
Journal:  Curr Opin Pediatr       Date:  2010-12       Impact factor: 2.856

Review 2.  Cytosine arabinoside in the treatment of acute myeloid leukemia: the role and place of high-dose regimens.

Authors:  W Hiddemann
Journal:  Ann Hematol       Date:  1991-04       Impact factor: 3.673

Review 3.  Causes and problems of nonresponse or poor response to drugs.

Authors:  P Salvà Lacombe; J A García Vicente; J Costa Pagès; P Lucio Morselli
Journal:  Drugs       Date:  1996-04       Impact factor: 9.546

4.  Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine.

Authors:  G W Visser; O Zwaagstra; G C Gorree; P Moonen; J D Herscheid; A Hoekstra
Journal:  Eur J Nucl Med       Date:  1986

Review 5.  The discovery of first-in-class drugs: origins and evolution.

Authors:  Jörg Eder; Richard Sedrani; Christian Wiesmann
Journal:  Nat Rev Drug Discov       Date:  2014-07-18       Impact factor: 84.694

6.  Quantitation of synergism of arabinosylcytosine and cladribine against the growth of arabinosylcytosine-resistant human lymphoid cells.

Authors:  Tieran Han; Marilyn Fernandez; Ting-Chao Chou; Ram P Agarwal
Journal:  J Cancer Res Clin Oncol       Date:  2005-10-20       Impact factor: 4.553

Review 7.  High-dose cytosine arabinoside: pharmacological and clinical aspects.

Authors:  W G Peters; L P Colly; R Willemze
Journal:  Blut       Date:  1988-01

8.  The immunosuppressive activity of adamantoyl cytarabine. 3. Immunosuppressive specificity in rats.

Authors:  G D Gray; M M Mickelson
Journal:  Immunology       Date:  1970-09       Impact factor: 7.397

9.  Combination of fludarabine and arabinosylcytosine for treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology.

Authors:  V Gandhi; L E Robertson; M J Keating; W Plunkett
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

10.  Synergistic interaction between 1-beta-D-arabinofuranosylcytosine, thymidine, and hydroxyurea against human B cells and leukemic blasts in vitro.

Authors:  J A Streifel; S B Howell
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205
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