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Literature DB >> 2428619

Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine.

G W Visser, O Zwaagstra, G C Gorree, P Moonen, J D Herscheid, A Hoekstra.

Abstract

[18F]-5-fluorocytosine-arabinoside (2) and [18F]-5-fluorocyclocytidine (4) were prepared by reaction of [18F]-acetylhypofluorite with cytosine-arabinoside (1) or cyclocytidine (3) in acetic acid and were isolated in an overall radiochemical yield of 20% and 9%, respectively. The biodistribution of both radiopharmaceuticals was determined in melanoma bearing Syrian golden hamsters. It was found that 2 is a good tumour-localizing agent for pigmented and non-pigmented Greene melanoma.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 2428619 DOI： 10.1007/bf00276706

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

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References

13 in total

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10. Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.

Authors: J H Turner; M Maziere; D Comar
Journal: Eur J Nucl Med Date: 1985

Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine.

1. Nucleic acid related compounds. 21. Direct fluorination of uracil and cytosine bases and nucleosides using trifluoromethyl hypofluorite. Mechanism, stereochemistry, and synthetic applications.

2. Metabolism and intracellular retention of 1-beta-D-arabinofuranosylcytosine as predictors of response of animal tumors.

3. Dose schedule and antitumor studies of arabinosyl cytosine (NSC 63878).

4. Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy.

5. Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo.

Review 6. Cytosine arabinoside: molecular, pharmacokinetic and cytokinetic considerations.

7. Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside.

8. Clincal pharmacology of O2,2'-cyclocytidine.

9. Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters.

10. Localization of 11C-radiopharmaceuticals in the Greene melanoma of hamsters.