Literature DB >> 6025125

Conversion of beta sitosterol to cholesterol blocked in an insect by hypocholesterolemic agents.

J A Svoboda, W E Robbins.   

Abstract

Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of beta-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion-the reduction of desmosterol (24-dehydrocholesterol) to cholesterol. This is also the site at which these compounds inhibit de novo cholesterol biosynthesis in higher animals. Both agents severely inhibit growth and maturation of the tobacco hornworm.

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Year:  1967        PMID： 6025125     DOI： 10.1126/science.156.3782.1637

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  Nonsteroidal secondary and tertiary amines: inhibitors of insect development and metamorphosis and delta-24-sterol reductase system of tobacco hornworm.

Authors:  W E Robbins; M J Thompson; J A Svoboda; T J Shortino; C F Cohen; S R Dutky; O J Duncan
Journal:  Lipids       Date:  1975-06       Impact factor: 1.880

Review 2.  Role of sterols in membranes.

Authors:  W R Nes
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

3.  Effects of triparanol and AY-9944 upon sterol biosynthesis in Chorella.

Authors:  G W Patterson; P J Doyle; L G Dickson; J T Chan
Journal:  Lipids       Date:  1974-08       Impact factor: 1.880

4.  [Intermediates from dealkylation at C 24 of beta-sitosterol by the cricket Locusta migratoria L].

Authors:  J P Allais; M Barbier
Journal:  Experientia       Date:  1971-05-15

5.  Desmosterol as a common intermediate in the conversion of a number of C28 and C29 plant sterols to cholesterol by the tobacco hornworm.

Authors:  J A Svoboda; W E Robbins
Journal:  Experientia       Date:  1968-11-15

6.  The influence of several sterols on the conversion of beta-sitosterol into cholesterol in the cockroach.

Authors:  W H Wientjens; T Van der Marel; E P Bennett
Journal:  Experientia       Date:  1971-04-15

7.  Fungal transformations of triparanol.

Authors:  S A Warner; G W Sovocool; A J Domnas
Journal:  Appl Environ Microbiol       Date:  1982-12       Impact factor: 4.792

Review 8.  Regulation of the sequencing in sterol biosynthesis.

Authors:  W R Nes
Journal:  Lipids       Date:  1971-04       Impact factor: 1.880

9.  Insect steroid metabolism.

Authors:  J A Svoboda; M J Thompson; W E Robbins; J N Kaplanis
Journal:  Lipids       Date:  1978-10       Impact factor: 1.880

10.  Mechanism of dealkylation of clionasterol in the insect Tenebrio molitor.

Authors:  P J Pettler; W J Lockley; H H Rees; T W Goodwin
Journal:  Biochem J       Date:  1978-08-15       Impact factor: 3.857
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