Literature DB >> 6015874

Genomic exclusion: a rapid means for inducing homozygous diploid lines in Tetrahymena pyriformis, syngen 1.

S L Allen.   

Abstract

Genomic exclusion is an abnormal form of conjugation occurring between cells with defective micronuclei and normal cells with diploid micronuclei. The progeny are heterocaryons; each cell has an old macronucleus but a new diploid micronucleus derived from one meiotic product of the normal mate. Such cells express genes found in the old macronucleus, are sexually mature, and can be specifically selected. When inbred, they give rise to lines genetically homozygous at all known loci.

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Year:  1967        PMID： 6015874     DOI： 10.1126/science.155.3762.575

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  40 in total

1.  A late-determined gene in tetrahymena heterozygotes.

Authors:  S L Allen
Journal:  Genetics       Date:  1971-07       Impact factor: 4.562

Review 2.  Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools.

Authors:  Marisa D Ruehle; Eduardo Orias; Chad G Pearson
Journal:  Genetics       Date:  2016-06       Impact factor: 4.562

3.  Germ-line knockout heterokaryons of an essential alpha-tubulin gene enable high-frequency gene replacement and a test of gene transfer from somatic to germ-line nuclei in Tetrahymena thermophila.

Authors:  B Hai; M A Gorovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

4.  High frequency intragenic recombination during macronuclear development in Tetrahymena thermophila restores the wild-type SerH1 gene.

Authors:  J C Deak; F P Doerder
Journal:  Genetics       Date:  1998-03       Impact factor: 4.562

5.  Germline and somatic transformation of mating Tetrahymena thermophila by particle bombardment.

Authors:  D Cassidy-Hanley; J Bowen; J H Lee; E Cole; L A VerPlank; J Gaertig; M A Gorovsky; P J Bruns
Journal:  Genetics       Date:  1997-05       Impact factor: 4.562

6.  Selective mirror-image reversal of ciliary patterns inTetrahymena thermophila homozygous for ajanus mutation.

Authors:  Joseph Frankel; Leslie Meek Jenkins; Julita Bakowska
Journal:  Wilehm Roux Arch Dev Biol       Date:  1984-02

7.  Interactions between janus and bcd cortical pattern mutants in Tetrahymena thermophila : An investigation of intracellular patterning mechanisms using double-mutant analysis.

Authors:  Eric Stephen Cole; Joseph Frankel; Leslie Meek Jenkins
Journal:  Rouxs Arch Dev Biol       Date:  1988-01

8.  A drug-resistant mutation in the ribosomal DNA of Tetrahymena.

Authors:  P J Bruns; A L Katzen; L Martin; E H Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

9.  Tetrahymena in the laboratory: strain resources, methods for culture, maintenance, and storage.

Authors:  Donna M Cassidy-Hanley
Journal:  Methods Cell Biol       Date:  2012       Impact factor: 1.441

10.  Isolation of homozygous mutants after induced self-fertilization in Tetrahymena.

Authors:  P J Bruns; T B Brussard; A B Kavka
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205
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