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Literature DB >> 5968015

The metabolic fate of tolbutamide in man and in the rat.

R C Thomas, G J Ikeda.

Abstract

Entities: Chemical Species

Mesh：

Substances：
Tritium
Tolbutamide

Year: 1966 PMID： 5968015 DOI： 10.1021/jm00322a014

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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37 in total

1. Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.

Authors: S Kanamitsu; K Ito; Y Sugiyama
Journal: Pharm Res Date: 2000-03 Impact factor: 4.200

2. Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I.

Authors: H Umesha Shetty; Sami S Zoghbi; Jeih-San Liow; Masanori Ichise; Jinsoo Hong; John L Musachio; Christer Halldin; Jurgen Seidel; Robert B Innis; Victor W Pike
Journal: Eur J Nucl Med Mol Imaging Date: 2006-11-10 Impact factor: 9.236

3. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance.

Authors: W Zilly; D D Breimer; E Richter
Journal: Eur J Clin Pharmacol Date: 1975-12-19 Impact factor: 2.953

Review 4. Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

Authors: Julia Kirchheiner; Ivar Roots; Mark Goldammer; Bernd Rosenkranz; Jürgen Brockmöller
Journal: Clin Pharmacokinet Date: 2005 Impact factor: 6.447

The metabolic fate of tolbutamide in man and in the rat.

1. Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.

2. Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I.

3. Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance.

Review 4. Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

Review 5. The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation.

6. Lack of efficacy of cimetidine and ranitidine as inhibitors of tolbutamide metabolism.

Review 7. Insulin and oral hypoglycaemic agents. I. Physiological and clinical pharmacological aspects.

8. Tolbutamide 4-hydroxylase activity of human liver microsomes: effect of inhibitors.

9. Alteration of drug metabolism in Gilbert's syndrome.

Review 10. Pharmacokinetics of oral antihyperglycaemic agents in patients with renal insufficiency.