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Literature DB >> 593275

Effect of ethionine on the rough endoplasmic reticulum from male and female rat liver.

H H Czosnek, A Ascarelli, N De Groot, M Hergenhahn, A A Hochberg.

Abstract

Ethionine causes a decrease in the amount of rough endoplasmic reticulum in rat liver, the effect being greater in female than in male rats. Rough endoplasmic reticulum isolated from rat liver 24 hr after ethionine injection and stripped of its ribosomes partially lost its in vitro ribosome binding capacity. However, no differences were detected between the binding affinities of ribosomes, isolated from either untreated animals or intoxicated rats, to stripped rough membranes derived from normal rats. Structural changes occur in the rough endoplasmic reticulum of the ethionine treated rats, while the ribosomes are still bound to the membrane.

Entities: Chemical Species

Mesh：

Substances：
Ethionine

Year: 1977 PMID： 593275 DOI： 10.1007/bf00808388

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

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References

15 in total

1. The separation of rat liver endoplasmic reticulum membrane proteins by two dimensional polyacrylamide gel electrophoresis.

Authors: H H Czosnek; A A Hochberg
Journal: Mol Biol Rep Date: 1975-03 Impact factor: 2.316

2. The in vitro reconstitution of a functional rough membrane active in protein synthesis.

Authors: A A Hochberg; H H Czosnek; T Shine; N De Groot
Journal: Mol Biol Rep Date: 1975-03 Impact factor: 2.316

3. Structure of rough, smooth, stripped and reconstituted rough membranes derived from rat liver as visualized by the freeze fracture technique.

Authors: A A Hochberg; H H Czosnek; Y Reichler; I Ohad; N De Groot
Journal: Mol Biol Rep Date: 1975-12 Impact factor: 2.316

Review 4. ATP and cell integrity.

Authors: E Farber
Journal: Fed Proc Date: 1973-04

10. Mobility of ribosomes bound to microsomal membranes. A freeze-etch and thin-section electron microscope study of the structure and fluidity of the rough endoplasmic reticulum.

Authors: G K Ojakian; G Kreibich; D D Sabatini
Journal: J Cell Biol Date: 1977-03 Impact factor: 10.539

Effect of ethionine on the rough endoplasmic reticulum from male and female rat liver.

1. The separation of rat liver endoplasmic reticulum membrane proteins by two dimensional polyacrylamide gel electrophoresis.

2. The in vitro reconstitution of a functional rough membrane active in protein synthesis.

3. Structure of rough, smooth, stripped and reconstituted rough membranes derived from rat liver as visualized by the freeze fracture technique.

Review 4. ATP and cell integrity.

5. A microsomal membrane alteration following ethionine intoxication.

6. Endoplasmic membrane degranulation in vivo as a result of ethionine intoxication.

7. Reactivity of analogues of S-adenosylmethionine in the enzymic synthesis of spermidine by mammalian tissues.

8. Biochemical studies on the mechanism of action of liver poisons. II. Induction of fatty livers.

9. Fracture faces of frozen membranes.

10. Mobility of ribosomes bound to microsomal membranes. A freeze-etch and thin-section electron microscope study of the structure and fluidity of the rough endoplasmic reticulum.