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Literature DB >> 5922533

Biological properties of alpha-toxin mutants of Staphylococcus aureus.

Abstract

McClatchy, J. K. (The University of Texas Southwestern Medical School, Dallas), and E. D. Rosenblum. Biological properties of alpha-toxin mutants of Staphylococcus aureus. J. Bacteriol. 92:575-579. 1966.-Twenty nonhemolytic mutants of Staphylococcus aureus were isolated after treatment of a hemolytic strain with ultraviolet light or nitrous acid. Thirteen strains isolated were completely lacking in the synthesis of alpha toxin or immunologically related proteins, presumably the result of a single mutational event. Although the strains were nonhemolytic on rabbit blood-agar plates, six of them retained the dermonecrotic and lethal activities usually associated with staphylococcal alpha toxin, as well as slight hemolytic activity for rabbit erythrocyte suspensions. The active mutants and one inactive mutant produced a protein that reacted immunologically with antibody to alpha toxin. Mutations which alter the alpha toxin molecule can effect the lethal, dermonecrotic, and hemolytic activities separately or in varying ratios.

Entities: Chemical Species

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Year: 1966 PMID： 5922533 PMCID： PMC276291 DOI： 10.1128/jb.92.3.575-579.1966

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

16 in total

1. ACTION OF STAPHYLOCOCCAL TOXIN ON HUMAN PLATELETS.

Authors: I SIEGEL; S COHEN
Journal: J Infect Dis Date: 1964-12 Impact factor: 5.226

2. EFFECT OF STAPHYLOCOCCAL AND OTHER BACTERIAL TOXINS ON PLATELETS IN VITRO.

Authors: A W BERNHEIMER; L L SCHWARTZ
Journal: J Pathol Bacteriol Date: 1965-01

3. Specificity and catalytic power in enzyme action.

Authors: D E KOSHLAND; J A YANKEELOV; J A THOMA
Journal: Fed Proc Date: 1962 Nov-Dec

4. The tryptophan synthetase system.

Authors: C YANOFSKY
Journal: Bacteriol Rev Date: 1960-06

5. A simplified micro double-diffusion agar precipitin technique.

Authors: A J CROWLE
Journal: J Lab Clin Med Date: 1958-11

6. Biological characteristics of staphylococci that may relate to virulence; biological characteristics of staphylococci recovered from pathologic materials.

Authors: C H LACK
Journal: Ann N Y Acad Sci Date: 1956-08-31 Impact factor: 5.691

7. The Production of Staphylococcal Alpha-Hemolysin: The Rôle of Agar.

Authors: E P Casman
Journal: J Bacteriol Date: 1940-11 Impact factor: 3.490

8. SEROLOGY AND TRANSDUCTION IN STAPHYLOCOCCAL PHAGE.

Authors: C E Dowell; E D Rosenblum
Journal: J Bacteriol Date: 1962-11 Impact factor: 3.490

9. LYSIS OF BACTERIAL PROTOPLASTS AND SPHEROPLASTS BY STAPHYLOCOCCAL ALPHA-TOXIN AND STREPTOLYSIN S.

Authors: A W BERNHEIMER; L L SCHWARTZ
Journal: J Bacteriol Date: 1965-05 Impact factor: 3.490

10. The characterization of staphylococcal toxins. I. The electrophoretic migration of the alpha hemolytic, dermonecrotic, lethal, and leucocidal activities of crude toxin.

Authors: S KUMAR; R K LINDORFER
Journal: J Exp Med Date: 1962-06-01 Impact factor: 14.307

7 in total

Biological properties of alpha-toxin mutants of Staphylococcus aureus.

1. ACTION OF STAPHYLOCOCCAL TOXIN ON HUMAN PLATELETS.

2. EFFECT OF STAPHYLOCOCCAL AND OTHER BACTERIAL TOXINS ON PLATELETS IN VITRO.

3. Specificity and catalytic power in enzyme action.

4. The tryptophan synthetase system.

5. A simplified micro double-diffusion agar precipitin technique.

6. Biological characteristics of staphylococci that may relate to virulence; biological characteristics of staphylococci recovered from pathologic materials.

7. The Production of Staphylococcal Alpha-Hemolysin: The Rôle of Agar.

8. SEROLOGY AND TRANSDUCTION IN STAPHYLOCOCCAL PHAGE.

9. LYSIS OF BACTERIAL PROTOPLASTS AND SPHEROPLASTS BY STAPHYLOCOCCAL ALPHA-TOXIN AND STREPTOLYSIN S.

10. The characterization of staphylococcal toxins. I. The electrophoretic migration of the alpha hemolytic, dermonecrotic, lethal, and leucocidal activities of crude toxin.

1. Chromosomal map location of the alpha-hemolysin structural gene in Staphylococcus aureus NCTC 8325.

2. Genetic recombination between alpha-toxin mutants of Staphylococcus aureus.

3. Identification of a chromosomal determinant of alpha-toxin production in Staphylococcus aureus.

4. Isolation of mutants of Staphylococcus aureus lacking extracellular nuclease activity.

5. The role of humoral immunity and acute inflammation in protection against staphyloccocal dermonecrosis.

6. Protein A mutants of Staphylococcus aureus.

7. Pleiotropic alteration of activities of several toxins and enzymes in mutants of Staphylococcus aureus.