Literature DB >> 172896

A unique complement derived chemotactic factor for tumor cells.

A G Romualdez, P A Ward.   

Abstract

A factor chemotactic for Walker carcinosarcoma and Novikoff hepatoma tumor cells can be generated by incubation of serum with an extract from tumor cells. The chemotactic factor has no activity for neutrophilic leukocytes, and three factors chemotactic for leukocytes are not chemotactic for tumor cells. By the use of complement deficient serums as well as purified complement components, the chemotactic factor for tumor cells has been found to be a fragment of the fifth component (C5) of complement and appears to result from direct interaction of C5 with an enzyme in the extract. The chemotactic factor for tumor cells can be classified as a functionally unique fragment of C5 that may significantly influence the behavior of tumor cells in vivo.

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Year:  1975        PMID： 172896      PMCID： PMC433152          DOI： 10.1073/pnas.72.10.4128

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

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Journal:  Science       Date:  1970-12-04       Impact factor: 47.728

5.  Studies on the mechanisms of invasion in cancer. I. Isolation and purification of a factor chemotactic for cancer cells.

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Journal:  Int J Cancer       Date:  1970-07-15       Impact factor: 7.396

6.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

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Authors:  P A Ward; N J Zvaifler
Journal:  J Clin Invest       Date:  1971-03       Impact factor: 14.808

8.  Chemotoxis of mononuclear cells.

Authors:  P A Ward
Journal:  J Exp Med       Date:  1968-11-01       Impact factor: 14.307

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Authors:  J H Hill; P A Ward
Journal:  J Exp Med       Date:  1969-09-01       Impact factor: 14.307

10.  ISOLATION OF BETA IF-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT.

Authors:  U R NILSSON; H J MUELLER-EBERHARD
Journal:  J Exp Med       Date:  1965-08-01       Impact factor: 14.307
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  21 in total

1.  SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells.

Authors:  A Albini; G Allavena; H Richter; B F Pontz; S Parodi; L Santi
Journal:  Experientia       Date:  1985-12-15

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Authors:  S Aznavoorian; M L Stracke; H Krutzsch; E Schiffmann; L A Liotta
Journal:  J Cell Biol       Date:  1990-04       Impact factor: 10.539

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Journal:  Am J Pathol       Date:  1979-01       Impact factor: 4.307

4.  Chemotactic factor for tumor cells derived from the C5a fragment of complement component C5.

Authors:  W Orr; S H Phan; J Varani; P A Ward; D L Kreutzer; R O Webster; P M Henson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

Review 5.  Tumor invasion and host extracellular matrix.

Authors:  B U Pauli; D E Schwartz; E J Thonar; K E Kuettner
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

Review 6.  The role of cell adhesion proteins--laminin and fibronectin--in the movement of malignant and metastatic cells.

Authors:  J B McCarthy; M L Basara; S L Palm; D F Sas; L T Furcht
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

7.  The chemotactic response of tumor cells. A model for cancer metastasis.

Authors:  W C Lam; E J Delikatny; F W Orr; J Wass; J Varani; P A Ward
Journal:  Am J Pathol       Date:  1981-07       Impact factor: 4.307

8.  Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro.

Authors:  J B McCarthy; L T Furcht
Journal:  J Cell Biol       Date:  1984-04       Impact factor: 10.539

9.  Platelet factors induce chemotactic migration of murine mammary adenocarcinoma cells with different metastatic capabilities.

Authors:  M A Sarach; R A Rovasio; A R Eynard
Journal:  Int J Exp Pathol       Date:  1993-10       Impact factor: 1.925

10.  Generation of a complement-derived chemotactic factor for tumor cells in experimentally induced peritoneal exudates and its effect on the local metastasis of circulating tumor cells.

Authors:  F W Orr; S Mokashi; J Delikatny
Journal:  Am J Pathol       Date:  1982-07       Impact factor: 4.307
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