Literature DB >> 591459

New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces.

S Omura, H Tanaka, R Oiwa, J Awaya, R Masuma, K Tanaka.   

Abstract

New antibiotics, OS-4742 A1, A2, B1 and B2, were isolated from the culture broth of the strain OS-4742, which was designated as Streptomyces matensis subsp. vineus. These compounds have anthracycline chromophores and sugar moieties, but do not contain nitrogen. They possess antimicrobial activities against Gram-positive bacteria and antitumor activities against S-180 solid tumor on mice.

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Year:  1977        PMID： 591459     DOI： 10.7164/antibiotics.30.908

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  C-Aryl glycosides via tandem intramolecular benzyne-furan cycloadditions. Total synthesis of vineomycinone B2 methyl ester.

Authors:  Chi-Li Chen; Steven M Sparks; Stephen F Martin
Journal:  J Am Chem Soc       Date:  2006-10-25       Impact factor: 15.419

Review 2.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

3.  De novo asymmetric synthesis of fridamycin E.

Authors:  Qian Chen; Michael Mulzer; Pei Shi; Penny J Beuning; Geoffrey W Coates; George A O'Doherty
Journal:  Org Lett       Date:  2011-11-22       Impact factor: 6.005

Review 4.  Antitumor compounds from marine actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Mar Drugs       Date:  2009-06-11       Impact factor: 5.118

5.  Convergent de novo synthesis of vineomycinone B2 methyl ester.

Authors:  Qian Chen; Yashan Zhong; George A O'Doherty
Journal:  Chem Commun (Camb)       Date:  2013-08-04       Impact factor: 6.222

6.  Tandem Intramolecular Benzyne-Furan Cycloadditions. Total Synthesis of Vineomycinone B(2) Methyl Ester.

Authors:  Steven M Sparks; Chi-Li Chen; Stephen F Martin
Journal:  Tetrahedron       Date:  2007-08-27       Impact factor: 2.457

7.  Cytotoxic and antibacterial angucycline- and prodigiosin-analogues from the deep-sea derived Streptomyces sp. SCSIO 11594.

Authors:  Yongxiang Song; Guangfu Liu; Jie Li; Hongbo Huang; Xing Zhang; Hua Zhang; Jianhua Ju
Journal:  Mar Drugs       Date:  2015-03-16       Impact factor: 5.118

8.  Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria.

Authors:  Rima Ouchene; Didier Stien; Juliette Segret; Mouloud Kecha; Alice M S Rodrigues; Carole Veckerlé; Marcelino T Suzuki
Journal:  Front Microbiol       Date:  2022-06-23       Impact factor: 6.064
  8 in total

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