Literature DB >> 591447

Synthesis and antibacterial activities of 1-N [(S)-omega-amino-2-hydroxyalkyl] kanamycin A derivatives.

K Richardson, S Jevons, J W Moore, B C Ross, J R Wright.   

Abstract

Four 1-N-aminohydroxy-alkyl derivatives of kanamycin A were prepared and their in vitro activities against aminoglycoside-sensitive and aminoglycoside-resistant organisms were compared with amikacin. 1-N-[(S)-4-Amino-2-hydroxybutyl] kanamycin A (Fig. 1, compound 2, code no. UK-18,892) was equipotent to amikacin in all these tests and in mouse protection studies.

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Year:  1977        PMID： 591447     DOI： 10.7164/antibiotics.30.843

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

Review 1.  Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors:  K E Price
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

2.  UK-18,892: resistance to modification by aminoglycoside-inactivating enzymes.

Authors:  R J Andrews; K W Brammer; H E Cheeseman; S Jevons
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

3.  UK-18892, a new aminoglycoside: an in vitro study.

Authors:  R Wise; J M Andrews
Journal:  Antimicrob Agents Chemother       Date:  1978-08       Impact factor: 5.191

4.  Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.

Authors:  Eijiro Umemura; Yukou Sakamoto; Yoshiaki Takahashi; Toshiaki Miyake
Journal:  J Antibiot (Tokyo)       Date:  2015-02-25       Impact factor: 2.649

5.  In vitro studies with UK-18,892, a new aminoglycoside antibiotic.

Authors:  S Jevons; H E Cheeseman; K W Brammer
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

6.  Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.

Authors:  A J Carter
Journal:  Antimicrob Agents Chemother       Date:  1979-09       Impact factor: 5.191
  6 in total

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