Literature DB >> 507791

Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.

A J Carter.   

Abstract

The cochleotoxic potential of butikacin (UK-18,892), a new semisynthetic aminoglycoside, has been evaluated in neonatal guinea pigs in comparison with amikacin, gentamicin, and kanamycin A. All compounds produced a dose-related increase of the mean threshold sound intensity required to elicit Preyer's reflex. Butikacin produced a similar level of cochlear toxicity to that of kanamycin A, but tended to be less cochleotoxic than amikacin. Gentamicin was the least cochleotoxic.

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Year:  1979        PMID： 507791      PMCID： PMC352861          DOI： 10.1128/AAC.16.3.362

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Ototoxicity of neomycin and other antibiotics.

Authors:  W LEACH
Journal:  J Laryngol Otol       Date:  1962-10       Impact factor: 1.469

2.  The ototoxicity of kanamycin.

Authors:  J E HAWKINS
Journal:  Ann Otol Rhinol Laryngol       Date:  1959-09       Impact factor: 1.547

3.  Ototoxicity of amikacin.

Authors:  R E Black; W K Lau; R J Weinstein; L S Young; W L Hewitt
Journal:  Antimicrob Agents Chemother       Date:  1976-06       Impact factor: 5.191

4.  Ototoxicity studies with BB-K8, a new semisynthetic aminoglycoside antibiotic.

Authors:  J C Reiffenstein; S W Holmes; G H Hottendorf; M E Bierwagen
Journal:  J Antibiot (Tokyo)       Date:  1973-02       Impact factor: 2.649

Review 5.  Ototoxicity: a clinical review.

Authors:  J Ballantyne
Journal:  Audiology       Date:  1973 Sep-Dec

6.  Ototoxicity of gentamicin.

Authors:  J Wersäll; P G Lundquist; B Björkroth
Journal:  J Infect Dis       Date:  1969 Apr-May       Impact factor: 5.226

Review 7.  Parenteral aminoglycoside antibiotics--1977. Clinical use.

Authors:  M S Simberkoff; J J Rahal
Journal:  N Y State J Med       Date:  1977-01

8.  A screen for assessing the audio-toxic potential of aminoglycoside antibiotics [proceedings].

Authors:  J R Baird; A J Carter
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

9.  Synthesis and antibacterial activities of 1-N [(S)-omega-amino-2-hydroxyalkyl] kanamycin A derivatives.

Authors:  K Richardson; S Jevons; J W Moore; B C Ross; J R Wright
Journal:  J Antibiot (Tokyo)       Date:  1977-10       Impact factor: 2.649
  9 in total
  1 in total

1.  Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.

Authors:  Eijiro Umemura; Yukou Sakamoto; Yoshiaki Takahashi; Toshiaki Miyake
Journal:  J Antibiot (Tokyo)       Date:  2015-02-25       Impact factor: 2.649
  1 in total

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