Literature DB >> 591118

Effect of thymectomy on lymphocyte subpopulations in the pig. Demonstration of a thymus-dependent 'null' cell.

R M Binns, V Pallares, D B Symons, P Sibbons.   

Abstract

Thymectomy in neonatal pigs results in marked lymphopenia. Surface Ig immunofluorescence, Fc rosettes and SRBC rosettes have been used to identify blood lymphocyte subpopulations. There was no marked reduction in numbers of cells in these subpopulations after thymectomy, although their proportion increased. This change was explained by a 90% reduction in 'null' lymphocytes, defined as those lacking sIg and Dextran SRBC receptor, which comprised 30-45% of blood lymphocytes.

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Year:  1977        PMID: 591118     DOI: 10.1159/000231915

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN: 0020-5915


  11 in total

1.  Differentiation between MHC-restricted and non-MHC-restricted porcine cytolytic T lymphocytes.

Authors:  T Pauly; E Weiland; W Hirt; C Dreyer-Bux; S Maurer; A Summerfield; A Saalmüller
Journal:  Immunology       Date:  1996-06       Impact factor: 7.397

2.  Discrimination between two subsets of porcine CD8+ cytolytic T lymphocytes by the expression of CD5 antigen.

Authors:  A Saalmüller; W Hirt; S Maurer; E Weiland
Journal:  Immunology       Date:  1994-04       Impact factor: 7.397

3.  Subpopulations of T lymphocytes emigrating in venous blood draining pig thymus labelled in vivo with fluorochrome.

Authors:  R M Binns; R Pabst; S T Licence
Journal:  Immunology       Date:  1988-02       Impact factor: 7.397

4.  Classification of newly formed and migrating splenic lymphocytes.

Authors:  R Pabst; S T Licence; R M Binns
Journal:  Clin Exp Immunol       Date:  1983-02       Impact factor: 4.330

5.  Classification of lymphocytes recirculating in the spleen.

Authors:  R M Binns; R Pabst; S T Licence
Journal:  Immunology       Date:  1981-10       Impact factor: 7.397

6.  The null T cell in pig blood is not an NK cell.

Authors:  I A Duncan; R M Binns; W P Duffus
Journal:  Immunology       Date:  1989-11       Impact factor: 7.397

7.  Genetically determined CD45 variant of value in leucocyte tracing in vivo in the pig.

Authors:  R M Binns; S T Licence; A Whyte; M Wilby; H J Rothkötter; M Bacon
Journal:  Immunology       Date:  1995-09       Impact factor: 7.397

Review 8.  Coevolution of T-cell receptors with MHC and non-MHC ligands.

Authors:  Caitlin D Castro; Adrienne M Luoma; Erin J Adams
Journal:  Immunol Rev       Date:  2015-09       Impact factor: 12.988

9.  Comparison of the direct antiglobulin rosetting reaction (DARR) and direct immunofluorescence (DIF) for demonstration of sIg-bearing lymphocytes in pigs, sheep and cattle.

Authors:  R M Binns; S T Licence; D B Symons; B W Gurner; R R Coombs; D E Walters
Journal:  Immunology       Date:  1979-03       Impact factor: 7.397

10.  Subsets of null and gamma delta T-cell receptor+ T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies.

Authors:  R M Binns; I A Duncan; S J Powis; A Hutchings; G W Butcher
Journal:  Immunology       Date:  1992-10       Impact factor: 7.397

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