Literature DB >> 5908074

Synchronization of mammalian cells with tritiated thymidine.

G F Whitmore, S Gulyas.   

Abstract

Short exposures of mammalian cells to tritiated thymidine of high specific activity destroys the proliferative capacity of mammalian cells. Since the killing is limited to cells that have synthesized DNA in the presence of the labeled compound, an exposure duration of less than one generation can yield a synchronized population.

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Year:  1966        PMID： 5908074     DOI： 10.1126/science.151.3711.691

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Mutant enrichment in the colonial alga, Eudorina elegans.

Authors:  A L Toby; C L Kemp
Journal:  Genetics       Date:  1975-10       Impact factor: 4.562

2.  Lethal response of HeLa cells to x-irradiation in the latter part of the generation cycle.

Authors:  T D Griffith; L J Tolmach
Journal:  Biophys J       Date:  1976-04       Impact factor: 4.033

3.  X-ray sensitivity of HeLa S3 cells in the G2 phase comparison of two methods of synchronization.

Authors:  B Djordjevic; L J Tolmach
Journal:  Biophys J       Date:  2008-12-31       Impact factor: 4.033

4.  Stimulation of DNA synthesis and complement-fixing antigen production by SV40 in human diploid cell cultures: evidence for "abortive" infection.

Authors:  G Sauer; V Defendi
Journal:  Proc Natl Acad Sci U S A       Date:  1966-08       Impact factor: 11.205

5.  Natural and induced synchronous cultures.

Authors:  G F Whitmore
Journal:  In Vitro       Date:  1971 Jan-Feb

6.  Synchronization of mouse L-cells by a velocity sedimentation technique.

Authors:  H R Macdonald; R G Miller
Journal:  Biophys J       Date:  1970-09       Impact factor: 4.033

7.  Isolation of temperature-sensitive mutants of L-cells.

Authors:  L H Thompson; R Mankovitz; R M Baker; J E Till; L Siminovitch; G F Whitmore
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

8.  Perturbation of DNA replication and cell cycle progression by commonly used [3H]thymidine labeling protocols.

Authors:  C A Hoy; E D Lewis; R T Schimke
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

9.  Actinomycin D: effects on mouse L-cells.

Authors:  S Bacchetti; G F Whitmore
Journal:  Biophys J       Date:  1969-12       Impact factor: 4.033

10.  Mitosis and the processes of differentiation of myogenic cells in vitro.

Authors:  R Bischoff; H Holtzer
Journal:  J Cell Biol       Date:  1969-04       Impact factor: 10.539
  10 in total

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