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Literature DB >> 5905245

The state of hemoglobin in sickled erythrocytes.

Abstract

Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably for the disease itself.

Entities: Disease

Mesh：

Substances：
Hemoglobins, Abnormal

Year: 1966 PMID： 5905245 PMCID： PMC2138140 DOI： 10.1084/jem.123.2.341

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

9 in total

1. Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.

Authors: V M INGRAM
Journal: Nature Date: 1957-08-17 Impact factor: 49.962

2. [Sickling of erythrocytes studied with polarized light & electron microscopes. II. Erythrocyte internal structure; comparison with intra-erythrocytic crystals].

Authors: M BESSIS; G NOMARSKI; J P THIERY; J BRETON-GORIUS
Journal: Rev Hematol Date: 1958 Apr-Jun

3. A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin.

Authors: V M INGRAM
Journal: Nature Date: 1956-10-13 Impact factor: 49.962

4. [Microscopic structure of erythrocytes with abnormal hemoglobin].

Authors: D G DERVICHIAN; G FOURNET; A GUINIER; E PONDER
Journal: Rev Hematol Date: 1952

5. A simplified technique for a large scale crystallization of human oxyhemoglobin; isomorphous transformations of hemoglobin and myoglobin in the crystalline state.

Authors: D L DRABKIN
Journal: Arch Biochem Date: 1949-03

6. X-ray and solubility studies of the haemoglobin of sickle-cell anaemia patients.

Authors: R R PERUTZ; A M LIQUORI; F EIRICH
Journal: Nature Date: 1951-06-09 Impact factor: 49.962

7. State of haemoglobin in sickle-cell anaemia.

Authors: M F PERUTZ; J M MITCHISON
Journal: Nature Date: 1950-10-21 Impact factor: 49.962

8. Sickle cell anemia a molecular disease.

Authors: L PAULING; H A ITANO
Journal: Science Date: 1949-11-25 Impact factor: 47.728

9. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors: E S REYNOLDS
Journal: J Cell Biol Date: 1963-04 Impact factor: 10.539

9 in total

13 in total

1. Structure of fibers of sickle cell hemoglobin.

Authors: S J Edelstein; J N Telford; R H Crepeau
Journal: Proc Natl Acad Sci U S A Date: 1973-04 Impact factor: 11.205

2. Structure of sickled erythrocytes and of sickle-cell hemoglobin fibers.

Authors: J T Finch; M F Perutz; J F Bertles; J Döbler
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

3. Structure of hemoglobin S fibers: optical determination of the molecular orientation in sickled erythrocytes.

Authors: J Hofrichter; D G Hendricker; W A Eaton
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

4. The fine structure of cell-free sickled hemoglobin.

Authors: J G White; B Heagan
Journal: Am J Pathol Date: 1970-01 Impact factor: 4.307

5. Tubular polymers of normal human hemoglobin.

Authors: J G White; B Heagan
Journal: Am J Pathol Date: 1970-04 Impact factor: 4.307

6. Sickling reversed and blocked by urea in invert sugar.

Authors: R M Nalbandian; R L Henry; M I Barnhart; B M Nichols; F R Camp; P L Wolf
Journal: Am J Pathol Date: 1971-08 Impact factor: 4.307

7. In vitro effects of anthocyanin extracts from Justicia secunda Vahl on the solubility of haemoglobin S and membrane stability of sickle erythrocytes.

Authors: Pius T Mpiana; KotoTe Niwa N Ngbolua; Matthieu T Bokota; Teddy K Kasonga; Emmanuel K Atibu; Damien S T Tshibangu; Virima Mudogo
Journal: Blood Transfus Date: 2010-10 Impact factor: 3.443