Literature DB >> 588240

Detection and quantitation of the fetal hemoglobin variant Hb F-Malta-I in adults.

G Altay, F Garver, W H Bannister, J L Grech, A Felice, T H Huisman.   

Abstract

A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific antisera. The concentration of Hb-F-Malta-I was 0.002-0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a ratio of about 27% in the newborn. Since the F-Malta-I variant is a product of a mutated Ggamma locus, which is one of the nonallelic structural genes directing the gamma chain synthesis, its presence in blood of adults shows that the synthesis of this gene is not completely suppressed after birth, as was previously suggested.

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Year:  1977        PMID： 588240     DOI： 10.1007/bf00483988

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  11 in total

1.  Specific radioimmunochemical identification and quantitation of hemoglobins A2 and F.

Authors:  F A Garver; C S Jones; M M Baker; G Altay; B P Barton; M Gravely; T H Huisman
Journal:  Am J Hematol       Date:  1976       Impact factor: 10.047

2.  A method of trace iodination of proteins for immunologic studies.

Authors:  P J McConahey; F J Dixon
Journal:  Int Arch Allergy Appl Immunol       Date:  1966

3.  Maternal synthesis of haemoglobin F in pregnancy.

Authors:  M E Pembrey; D J Weatherall; J B Clegg
Journal:  Lancet       Date:  1973-06-16       Impact factor: 79.321

4.  Non-synchronized suppression of postnatal activity in non-allelic genes which synthesize the Ggamma chain in human foetal haemoglobin.

Authors:  W A Schroeder; W H Bannister; J L Grech; A K Brown; R N Wrightstone; T H Huisman
Journal:  Nat New Biol       Date:  1973-07-18

5.  Evidence for four nonallelic structural genes for the chain of human fetal hemoglobin.

Authors:  T H Huisman; W A Schroeder; W H Bannister; J L Grech
Journal:  Biochem Genet       Date:  1972-10       Impact factor: 1.890

6.  Haemoglobin F(Malta): a new foetal haemoglobin variant with a high incidence in Maltese infants.

Authors:  M N Cauchi; J B Clegg; D J Weatherall
Journal:  Nature       Date:  1969-07-19       Impact factor: 49.962

7.  Glutaraldehyde-activated aminohexyl- derivative of Sepharose 4B as a new verstile immunoabsorbent.

Authors:  C L Cambiaso; A Goffinet; J P Vaerman; J F Heremans
Journal:  Immunochemistry       Date:  1975-04

8.  The inhibition of the primary interaction between 125I-labeled human hemoglobin and rabbit anti-human hemoglobin sera: a sensitive radioimmunoassay technique.

Authors:  F A Garver
Journal:  J Immunol Methods       Date:  1975-06       Impact factor: 2.303

9.  Variations in the frequency of fetal hemoglobin-bearing erythrocytes (F-cells) in well adults, pregnant women, and adult leukemics.

Authors:  S H Boyer; T K Belding; L Margolte; A N Noyes; P J Burke; W R Bell
Journal:  Johns Hopkins Med J       Date:  1975-09
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  1 in total

1.  Detection of proteins like human gamma and beta globins in Escherichia coli carrying recombinant DNA plasmids.

Authors:  L B Wilson; H E Grenett; D M Doran; F A Garver; J T Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205
  1 in total

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