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Literature DB >> 5866716

The metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species.

H Schumacher, R L Smith, R T Williams.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1965 PMID： 5866716 PMCID： PMC1510729 DOI： 10.1111/j.1476-5381.1965.tb02054.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

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6 in total

1. Teratogenic effects of thalidomide and related substances.

Authors: J B BOYLEN; H H HORNE; W J JOHNSON
Journal: Lancet Date: 1963-03-09 Impact factor: 79.321

2. Phthaloylisoglutamine, a metabolite of thalidomide.

Authors: R L SMITH; R A WILLIAMS; R T WILLIAMS
Journal: Life Sci (1962) Date: 1962-07

3. [On the behavior of thalidomide in the organism. 1].

Authors: R BECKMANN
Journal: Arzneimittelforschung Date: 1962-11

4. Some physico-chemical factors in drug action.

Authors: B B BRODIE; C A HOGBEN
Journal: J Pharm Pharmacol Date: 1957-06 Impact factor: 3.765

5. Enzymatic metabolism of drugs and other foreign compounds.

Authors: B B BRODIE; J R GILLETTE; B N LA DU
Journal: Annu Rev Biochem Date: 1958 Impact factor: 23.643

6. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution.

Authors: H Schumacher; R L Smith; R T Williams
Journal: Br J Pharmacol Chemother Date: 1965-10

6 in total

21 in total

1. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

Authors: Hiroshi Yamazaki; Hiroshi Suemizu; Makiko Shimizu; Sho Igaya; Norio Shibata; Masato Nakamura; Goutam Chowdhury; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2012-01-25 Impact factor: 3.739

2. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.

Authors: Goutam Chowdhury; Norie Murayama; Yusuke Okada; Yasuhiro Uno; Makiko Shimizu; Norio Shibata; F Peter Guengerich; Hiroshi Yamazaki
Journal: Chem Res Toxicol Date: 2010-06-21 Impact factor: 3.739

3. Differential effects of thalidomide on angiogenesis and tumor growth in mice.

Authors: A V Belo; M A Ferreira; A A Bosco; R D Machado; S P Andrade
Journal: Inflammation Date: 2001-04 Impact factor: 4.092

4. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

Authors: Hiroshi Yamazaki; Hiroshi Suemizu; Norie Murayama; Masahiro Utoh; Norio Shibata; Masato Nakamura; F Peter Guengerich
Journal: Chem Res Toxicol Date: 2013-03-01 Impact factor: 3.739

5. [What is the relevance of various previous lesions of the peripheral nervous system to a thalidomide polyneuropathy?].

Authors: G P Liebaldt; F Broser
Journal: Z Neurol Date: 1971

The metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species.

1. Teratogenic effects of thalidomide and related substances.

2. Phthaloylisoglutamine, a metabolite of thalidomide.

3. [On the behavior of thalidomide in the organism. 1].

4. Some physico-chemical factors in drug action.

5. Enzymatic metabolism of drugs and other foreign compounds.

6. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution.

1. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

2. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.

3. Differential effects of thalidomide on angiogenesis and tumor growth in mice.

4. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

5. [What is the relevance of various previous lesions of the peripheral nervous system to a thalidomide polyneuropathy?].

6. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution.

7. The metabolism of thalidomide: some biological effects of thalidomide and its metabolites.

Review 8. Potential novel uses of thalidomide: focus on palliative care.

9. In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice.

10. The rise, fall and subsequent triumph of thalidomide: lessons learned in drug development.