Literature DB >> 5844077

Uptake as a determinant of methotrexate response in mouse leukemias.

D Kessel, T C Hall, D Roberts, I Wodinsky.   

Abstract

Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r(2) = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.

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Year:  1965        PMID： 5844077     DOI： 10.1126/science.150.3697.752

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

Review 1.  ABC transporters and their role in nucleoside and nucleotide drug resistance.

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2.  Changes in muntjac fibroblasts associated with the acquisition of cadmium resistance. A pre-resistance, transitional and post-resistance study.

Authors:  M J Ord; R Chibber; S D Bouffler; T Courtney
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

3.  Genetically alterable transport of amethopterin in Diplococcus pneumoniae. II. Impairment of the system associated with various mutant genotypes.

Authors:  F M Sirotnak; M G Sargent; D J Hutchison
Journal:  J Bacteriol       Date:  1967-01       Impact factor: 3.490

Review 4.  Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.

Authors:  Rongbao Zhao; Larry H Matherly; I David Goldman
Journal:  Expert Rev Mol Med       Date:  2009-01-28       Impact factor: 5.600

5.  New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.

Authors:  F M Sirotnak; J I DeGraw; F A Schmid; L J Goutas; D M Moccio
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

6.  Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues.

Authors:  B A Chabner; R C Young
Journal:  J Clin Invest       Date:  1973-08       Impact factor: 14.808

Review 7.  Chemotherapeutic drug resistance in the management of head and neck cancer.

Authors:  H Bier
Journal:  Eur Arch Otorhinolaryngol       Date:  1993       Impact factor: 2.503

8.  Phase II trial of 10 deaza-aminopterin in patients with bladder cancer.

Authors:  T Ahmed; A Yagoda; H I Scher; C Sternberg; R C Watson
Journal:  Invest New Drugs       Date:  1986       Impact factor: 3.850

9.  Genetically alterable transport of amethopterin in Diplococcus pneumoniae. I. Physiological properties and kinetics of the wild-type system.

Authors:  F M Sirotnak; M G Sargent; D J Hutchison
Journal:  J Bacteriol       Date:  1967-01       Impact factor: 3.490

Review 10.  Role of laboratory chemosensitivity testing in the selection of cancer chemotherapy for individual patients.

Authors:  P J Selby; D Raghavan
Journal:  J Clin Pathol       Date:  1981-05       Impact factor: 3.411
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