Literature DB >> 582690

[The behaviour of codeine and codeine-6-glucuronide in hydrolysis with hydrochloric acid (author's transl)].

S Goenechea, K Kobbe, K J Goebel.   

Abstract

The behaviour of codeine and codeine-6-glucuronide with hydrochloric acid has been investigated. Three methods of hydrolysis were selected; they are often used in routine identification of drugs in urine. With method I (12--13% HCl; 30 min at 100 degrees C) about 53% of codeine-6-glucuronide were not hydrolized. The corresponding values: with method II (20% HCl; 6 min heated azeotrope in open vessel) about 8% and with method III (nearly 5% HCl; 30 min at 100 degrees C) about 83%.

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Year:  1978        PMID： 582690

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  6 in total

1.  [Behaviour of p-nitrophenol-glucuronide in hydrolysis with mineral acids (author's transl)].

Authors:  S Goenechea; K Kobbe; K J Goebel
Journal:  Z Rechtsmed       Date:  1979-04-27

2.  [Methodology and interpretation of morphiate detection in urine samples].

Authors:  G Sticht; H Käferstein; M Staak
Journal:  Z Rechtsmed       Date:  1985

3.  [Behaviour of hydroxymethyl-methaqualone-glucuronide in hydrolysis with hydrochloric acid (author's transl)].

Authors:  S Goenechea; K Kobbe; K J Goebel
Journal:  Z Rechtsmed       Date:  1980

4.  [Detection of pentazocin (Fortral) in human urine: gas chromatographic/mass spectrometric studies].

Authors:  W Gielsdorf; E Klug; M Tümmers
Journal:  Z Rechtsmed       Date:  1982

5.  [Oral administration of activated charcoal-sorbitol suspension as first aid in prevention of poison resorption?].

Authors:  P Eyer; M Sprenger
Journal:  Klin Wochenschr       Date:  1991-11-26

6.  [Cleavage of synthetic pentazocine glucuronide with hydrochloric acid].

Authors:  S Goenechea; G Rücker; M Langer; M Neugebauer
Journal:  Z Rechtsmed       Date:  1985
  6 in total

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