Literature DB >> 5826527

DNA: reaction with chloroquine.

J L Allison, R L O'Brien, F E Hahn.   

Abstract

Diflerence spectrophotometry shows that double-stranded DNA produces mnarked changes in the absorption spectrum of chloroquine; only minor changes occur with single-stranded DNA. A DNA-chloroquine complex was demonstrated to sediment in the analytical ultracentrifuge. Chloroquine strongly elevated the thermal dissociation temperature, T(m), of DNA. It is concluded that the drug forms a complex with DNA by ionic interaction and stabilizes the helix.

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Year:  1965        PMID： 5826527     DOI： 10.1126/science.149.3688.1111

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

Review 1.  Antimalarial agents: mechanisms of action.

Authors:  P H Schlesinger; D J Krogstad; B L Herwaldt
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

2.  Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum.

Authors:  N Surolia; G Padmanaban
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

3.  [Culture technics applicable to erythrocyte stages of paludism parasites].

Authors: 
Journal:  Bull World Health Organ       Date:  1973       Impact factor: 9.408

4.  Comparison of the effects of excess vitamin A and high oxygen tension on in vitro epiphyseal plate growth. I. Morphologic response.

Authors:  C T Brighton; E A Schaffzin
Journal:  Calcif Tissue Res       Date:  1970

5.  Cultivation techniques for the erythrocytic stages of malaria parasites.

Authors:  P Bertagna; S Cohen; Q M Geiman; J Haworth; E Koenigk; W H Richards; P I Trigg
Journal:  Bull World Health Organ       Date:  1972       Impact factor: 9.408

6.  Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

Authors:  R L O'Brien; J G Olenick; F E Hahn
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

7.  Specificity of deoxyribonucleic Acid intercalating compounds in the control of phenylalanine ammonia lyase and pisatin levels.

Authors:  L A Hadwiger; M E Schwochau
Journal:  Plant Physiol       Date:  1971-03       Impact factor: 8.340

8.  Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy.

Authors:  Bojana Gligorijevic; Kyle Purdy; David A Elliott; Roland A Cooper; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2008-01-09       Impact factor: 1.759

9.  Mechanisms of inhibition of pyrimidine dimer formation in deoxyribonucleic acid by acridine dyes.

Authors:  B M Sutherland; J C Sutherland
Journal:  Biophys J       Date:  1969-03       Impact factor: 4.033

10.  Haemoglobin interference and increased sensitivity of fluorimetric assays for quantification of low-parasitaemia Plasmodium infected erythrocytes.

Authors:  Carlos Moneriz; Patricia Marín-García; José M Bautista; Amalia Diez; Antonio Puyet
Journal:  Malar J       Date:  2009-12-04       Impact factor: 2.979
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