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Literature DB >> 4888976

Mechanisms of inhibition of pyrimidine dimer formation in deoxyribonucleic acid by acridine dyes.

Abstract

The ultraviolet (UV)-induced formation of cyclobutyl pyrimidine dimers in Escherichia coli deoxyribonucleic acid (DNA) in vitro has been investigated in terms of the mechanism of inhibition by acridine dyes, the effect on dimer yield of specific singlet and triplet quenchers, and the mechanism of dimer formation. Our results indicate that (a) energy transfer is important in dimer reduction by acridines, (b) this transfer occurs from the singlet (S(1)) of DNA, and (c) at room temperature triplet quenchers do not reduce dimer yield in DNA.

Entities: Chemical Species

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Year: 1969 PMID： 4888976 PMCID： PMC1367569 DOI： 10.1016/S0006-3495(69)86387-3

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

24 in total

1. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

Authors: R B SETLOW; W L CARRIER
Journal: Proc Natl Acad Sci U S A Date: 1964-02 Impact factor: 11.205

2. PHOTOREVERSIBILITY OF INDUCED MUTATIONS IN A NONPHOTOREACTIVABLE STRAIN OF ESCHERICHIA COLI.

Authors: E M WITKIN; N A SICURELLA; G M BENNETT
Journal: Proc Natl Acad Sci U S A Date: 1963-12 Impact factor: 11.205

3. A small and inexpensive ultraviolet dose-rate meter useful in biological experiements.

Authors: J JAGGER
Journal: Radiat Res Date: 1961-04 Impact factor: 2.841

4. Damage by visible light to the acridine orange--DNA complex.

Authors: D FREIFELDER; P F DAVISON; E P GEIDUSCHEK
Journal: Biophys J Date: 1961-05 Impact factor: 4.033

5. The effect of paramagnetic substances on the conversion of some pyrimidines by ultraviolet radiation.

Authors: R BEUKERS; W BERENDS
Journal: Biochim Biophys Acta Date: 1960-03-11

6. Pyrimidine dimers in ultraviolet-irradiated DNA's.

Authors: R B Setlow; W L Carrier
Journal: J Mol Biol Date: 1966-05 Impact factor: 5.469

7. Dosimetry in photochemistry.

Authors: H E Johns
Journal: Photochem Photobiol Date: 1968-12 Impact factor: 3.421

8. Formation and destruction of pyrimidine dimers in polynucleotides by ultra-violet irradiation in the presence of proflavine.

Authors: R B Setlow; W L Carrier
Journal: Nature Date: 1967-03-04 Impact factor: 49.962

3. The primary UV lesions for reversion to prototrophy in auxotrophic Escherichia coli: inferences from studies of protection by acriflavine.

Authors: T Alper; A J Forage
Journal: Mol Gen Genet Date: 1974

Mechanisms of inhibition of pyrimidine dimer formation in deoxyribonucleic acid by acridine dyes.

1. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

2. PHOTOREVERSIBILITY OF INDUCED MUTATIONS IN A NONPHOTOREACTIVABLE STRAIN OF ESCHERICHIA COLI.

3. A small and inexpensive ultraviolet dose-rate meter useful in biological experiements.

4. Damage by visible light to the acridine orange--DNA complex.

5. The effect of paramagnetic substances on the conversion of some pyrimidines by ultraviolet radiation.

6. Pyrimidine dimers in ultraviolet-irradiated DNA's.

7. Dosimetry in photochemistry.

8. Formation and destruction of pyrimidine dimers in polynucleotides by ultra-violet irradiation in the presence of proflavine.

9. Evidence for intercalation of chloroquine into DNA.

10. Pyrimidine dimers in the DNA of Paramecium aurelia.

1. Sequence dependence of energy transfer in DNA oligonucleotides.

2. Protective effect of furocoumarins against 254-nm ultraviolet in Staphylococcus aureus.

3. The primary UV lesions for reversion to prototrophy in auxotrophic Escherichia coli: inferences from studies of protection by acriflavine.

4. Protection of irradiated lambda phage by methylated proflavine.

5. Inhibition of pyrimidine dimer formation in DNA by cationic molecules: role of energy transfer.

6. Influence of mercuric ions on the phosphorescence and photochemistry of DNA.

7. Protection of normal, lysogenic, and pyocinogenic strains against ultraviolet radiation by bound acriflavine.

8. Probes of DNA structure and interactions. Effects of copper II on ultraviolet-induced pyrimidine dimer formation.