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Literature DB >> 5814704

Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.

J W Shands, V Miller, H Martin, V Senterfitt.

Abstract

The mechanism of the hypoglycemic activity of endotoxin in hyperreactive BCG mice was investigated. The mechanism was found to be an inhibition of the synthesis of glucose from noncarbohydrate sources. The possibilities of an induced hypermetabolic state and an induced release of insulin in response to endotoxin as causes for the hypoglycemic response were essentially ruled out. In addition, no clear-cut evidence of an insulin-like action by endotoxin was found in the in vivo setting.

Entities: Chemical Disease Species

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Year: 1969 PMID： 5814704 PMCID： PMC284844 DOI： 10.1128/jb.98.2.494-501.1969

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

13 in total

1. HYPOGLYCEMIA FOLLOWING ENDOTOXIN ADMINISTRATION IN ANIMALS WITH LIVER DAMAGE.

Authors: W E FARRAR; J G WATSON
Journal: Proc Soc Exp Biol Med Date: 1964-03

2. Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.

Authors: E SUTER; E M KIRSANOW
Journal: Immunology Date: 1961-10 Impact factor: 7.397

3. Tissue metabolism in infection. DPNase activity, DPN levels, and DPN-linked dehydrogenases in tissues from normal and tuberculous mice.

Authors: A BEKIERKUNST; M ARTMAN
Journal: Am Rev Respir Dis Date: 1962-12

4. Localization of endotoxin in the walls of the peripheral vascular system during lethal endotoxemia.

Authors: H S RUBENSTEIN; J FINE; A H COONS
Journal: Proc Soc Exp Biol Med Date: 1962-11

5. An o-toluidine method for body-fluid glucose determination.

Authors: K M DUBOWSKI
Journal: Clin Chem Date: 1962 May-Jun Impact factor: 8.327

6. Inhibition of mitochondrial respiration and uncoupling of oxidative phosphorylation by fractions of the Shigella paradysenteriae type III-somatic antigen.

Authors: J MAGER; E THEODOR
Journal: Arch Biochem Biophys Date: 1957-03 Impact factor: 4.013

7. Influence of stress on distribution of endotoxin in RES determined by fluorescein antibody technic.

Authors: N CREMER; D W WATSON
Journal: Proc Soc Exp Biol Med Date: 1957-07

Review 8. The blockade of insulin secretion by mannoheptulose.

Authors: E Simon; P F Kraicer
Journal: Isr J Med Sci Date: 1966 Nov-Dec

9. The essential role of the liver in detoxification of endotoxin.

Authors: W E Farrar; L M Corwin
Journal: Ann N Y Acad Sci Date: 1966-06-30 Impact factor: 5.691

10. Studies of the mechanism of the hypoglycemic action of 4-pentenoic acid.

Authors: C Corredor; K Brendel; R Bressler
Journal: Proc Natl Acad Sci U S A Date: 1967-12 Impact factor: 11.205

15 in total

1. Effects of endotoxin on carbohydrate metabolism in inbred mice.

Authors: R S Roy; S I Vas; H G Robson
Journal: Can J Comp Med Date: 1976-10

2. Carbohydrate metabolism and survival of endotoxin-poisoned mice given tryptophan.

Authors: R J Moon
Journal: Infect Immun Date: 1972-03 Impact factor: 3.441

3. Effect of endotoxin on the activation of phosphoenolpyruvate carboxykinase by tryptophan.

Authors: D F Rippe; L J Berry
Journal: Infect Immun Date: 1972-07 Impact factor: 3.441

4. Effect of lipopolysaccharide and lipid A on mouse liver pyruvate kinase activity.

Authors: S M Smith; I S Snyder
Journal: Infect Immun Date: 1975-11 Impact factor: 3.441

5. Mechanisms of pathogenesis in Listeria monocytogenes infection. V. Early imbalance in host energy metabolism during experimental listeriosis.

Authors: R E McCallum; C P Sword
Journal: Infect Immun Date: 1972-06 Impact factor: 3.441